Journal of Blood & Lymph

Department of General Surgery, TianTan Hospital, Beijing, China

Publications

• Research Article   
  TM4SF1 is Essential for Embryonic Blood Vessel Development
  Author(s): Chi-Iou Lin, Anne Merley, Hiromi Wada, Jianwei Zheng and Shou-Ching S. Jaminet*
  
  Transmembrane-4 L-Six Family Member-1 (TM4SF1) is a small cell surface glycoprotein that is highly and selectively expressed on endothelial cells and mesenchymal stem cells. TM4SF1 regulates cellular functions by forming protein complexes called TMED (TM4SF1-enriched micro domains) that internalize via microtubules from the cell surface and transport recruited proteins to intracellular locations including the nucleus. Through a genetically manipulated mouse model, we demonstrate here that TM4SF1 is essential for blood vessel development. Tm4sf1 null embryos fail to develop blood vessels and experience lethality at E9.5. Tm4sf1 heterozygous embryos are smaller in body size during early embryonic development, and almost half die in utero due to intracranial hemorrhage in the intraventricular and subarachnoid space which becomes apparent by E17.5. Su.. Read More»
  DOI: 10.37421/2165-7831.2023.13.310

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