Molecular and Genetic Medicine

ISSN: 1747-0862

Open Access

Dossier C

Department of Pediatric Nephrology, Robert Debré Hospital, 48 bd Serurier 75019, APHP, Paris, France

  • Research Article   
    Influence of Polymorphisms on Mycophenolate Mofetil - Induced Diarrhoea in Renal Transplanted Children
    Author(s): Lancia P, De Beaumais T, Dossier C, Baudouin V, Ulinski T, Deschênes G and Jacqz-Aigrain E*

    Purpose: The objective of this study was to investigate the factors involved in mycophenolate mofetil (MMF) disposition on the risk of diarrhoea in renal transplanted children. Methods: Patients’ characteristics, immunosuppression and polymorphisms of UGT1A8, UGT1A9, UGT2B7, ABCC2, IMPDH1, and IMPDH2 genes were explored. Statistical analyses were performed using logistic regression. Results: Eighty three renal transplanted patients were included and 28/83 (33%) developed diarrhoea requiring MMF discontinuation or switched to the enteric-coated formulation EC-MPS during follow-up. In the multivariate analysis, the risk of diarrhoea was significantly higher in ABCC2 -24CC wild-type patients carrying IMPDH2 IVS7 + 10 T>C variant. Conclusion: IMPDH2.. Read More»
    DOI: 10.37421/jmgm.2020.14.460

    Abstract PDF

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