Vitamins & Minerals

ISSN: 2376-1318

Open Access

Teresa Evans


  • Research Article
    Effect of Obesity on Serum Vitamin D Metabolites Using Obese Zucker Rat Model
    Author(s): Stepan Melnyk, Teresa Evans, Soheila Korourian and Reza HakkakStepan Melnyk, Teresa Evans, Soheila Korourian and Reza Hakkak

    The obesity epidemic in the US has continued for over two decades as the proportion of overweight and obese adults in the population continues to rise. Also, obesity has been linked with the risk of development of various diseases such as diabetes, cardiovascular disease and certain types of cancers. There are conflicting reports about the effects of obesity on serum vitamin D levels in human and animal models. We hypothesize that obesity will affect the serum levels of vitamin D metabolites. Therefore, the objective of this study was to investigate the influence of obesity on the serum concentrations of two metabolites of vitamin D [25-(OH)-D and 1,25-(OH)2-D] in rats. Sixteen 5-week-old female Zucker rats (8 obese fa/fa and 8 lean) were acclimated for one week, and at the age of 42 days, the rats were housed 2 per cage with ad libitum access to water and AIN-93G diet. Rat.. Read More»
    DOI: 10.4172/vms.1000122

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