Clinical Depression

Silvina Tonarelli

Publications

• Research Article
  Pharmacogenetics of Antidepressants, A Review of Significant Genetic Variants in Different Populations
  Author(s): Cynthia Reyes-Barron, Silvina Tonarelli, Andrew Delozier, David F. Briones, Brenda B. Su, Lewis P. Rubin and Chun XuCynthia Reyes-Barron, Silvina Tonarelli, Andrew Delozier, David F. Briones, Brenda B. Su, Lewis P. Rubin and Chun Xu
  
  Major depressive disorder is a highly prevalent disease that is challenging to treat, often requiring medication and dose adjustments. Genetic factors play an important role in psychotropic medication responses. However, the translation of pharmacogenetics findings to clinical recommendations with regards to antidepressant responses is still in its early stages. We reviewed recent primary research articles, meta-analyses, and reviews on the pharmacogenetics of antidepressant treatment for major depressive disorder in different populations. We identified eight genes with likely associations with treatment responses and summarized genetic variants most likely to influence treatment responses. We determined the frequency of these variants in Caucasian, Asian, Hispanic, and African American populations. The genes are related to functions in drug metabolism, transport, signalling, stress r.. Read More»
  

  Abstract PDF