Journal of Bioanalysis & Biomedicine

Priyadarshini Singh

Publications

• Research Article
  Analytical Quality-By-Design Compliant Ultrafast Liquid Chromatographic Method for Determination of Paliperidone in Extended Release Tablet Dosage Form
  Author(s): Sagar Suman Panda, Sarwar Beg, Ravi Kumar, Vankata Varaha Bera and Priyadarshini SinghSagar Suman Panda, Sarwar Beg, Ravi Kumar, Vankata Varaha Bera and Priyadarshini Singh
  
  The current study deals with development and validation of a simple, fast and sensitive ultrafast liquid chromatographic method using the cardinal principles of analytical quality by design for estimation of paliperidone in extended release pharmaceutical dosage form. A Box-Behnken design was adopted for optimizing chromatographic conditions, especially the method robustness by selecting organic phase composition, mobile phase flow rate and strength of tetra butyl ammonium hydrogen sulfate solution as the factors, and evaluating their effect on the responses like, retention time and tailing factor. The chromatography was performed on a C-18 column (250 × 4.6 mm, 5 μm) using methanol: 10 mM tetra butyl ammonium hydrogen sulfate (95:5% v/v) as mobile phase at flow rate of 1.0 ml/min with photodiode array detection at 279 nm. Method validation studi.. Read More»
  DOI: 10.4172/1948-593X.1000133

  Abstract PDF