Journal of Bioanalysis & Biomedicine

Ilbeyi Agabeyoglu

Publications

• Research Article
  Pharmacokinetic Modelling of Lamotrigine from Plasma Concentrations in Healthy Volunteers
  Author(s): Ilbeyi Agabeyoglu and Tuba IncecayirIlbeyi Agabeyoglu and Tuba Incecayir
  
  T he phar macokinetics of the antiepileptic a gent lamotrigine (CAS 84057-84-1) was investigated after single oral doses in 14 healthy volunteers. After t he ad- ministration of single oral doses of 2x100 mg lamot rigine chewable/soluble tablets to healthy volunteers, blo od samples were collected for the next 96 h. The pharm aco- kinetic modelling of lamotrigine showed that the dr ug exhibited two compartment open model with regard to the goodness of fits, Residual Sum of Squares (RSS), Ak aike’s Information Criteria (AIC), Schwartz Criteria (SC), stan- dard deviation of the regression (Sr), and determin ation coefficient (r 2 ). The time-concentration curves showed a mean time to reach peak plasma concentration, C max (t max ) of 2.0 h. The pharmacokinetic parameters were calcu lated based on the plasma curves. Area under the curve.. Read More»
  DOI: 10.4172/1948-593X.1000009

  Abstract PDF