Journal of Bioprocessing & Biotechniques

Chieh-Jen Wu

Publications

• Research Article
  Enhancement of Triterpenoids Production of Antrodia cinnamomea by Co-Culture with Saccharomyces cerevisiae
  Author(s): Chin-Hang Shu, Chieh-Jen Wu and Wen-Ju HsiaoChin-Hang Shu, Chieh-Jen Wu and Wen-Ju Hsiao
  
  Antrodia cinnamomea (AC) has attracted much attention recently due to its pharmacological benefits, especially for anticancer, and immunomodulation effects. Triterpenoids are the major bioactive compounds present in AC, and responsible for cancer curing ability. Oxygen supply to fermentation is a crucial environmental parameter affecting triterpenoids production. Thus, 29.6 mg/g biomass dry weight (DW) of triterpenoids was obtained by static operation (limited oxygen supply) in the second stage of monoculture of AC. In this paper, we propose a novel approach to enhancing triterpenoids production of AC through two-stage fermentation by co-culture with Saccharomyces cerevisiae in the second stage under limited oxygen supply. As a result, 38.0 mg/g DW of triterpenoids was obtained in 250 ml shake flask. Triterpenoid content was further enhan.. Read More»
  DOI: 10.4172/2155-9821.1000253

  Abstract PDF