Background: Periarthritis Shoulder (PAS) is a major musculoskeletal disability characterized by insidious onset, progressive pain and loss of active and passive mobility in the glenohumeral joint. The incidence of PAS is between 3%-5% in the general population and as high as 20% among individuals with diabetes. According to Traditional Chinese Medicine, Cupping therapy and Acupuncture plays major role in treating PAS. Cupping therapy is the ancient technique of healing which restores the balance between Yin-Yang by strengthening the body resistance, ejecting the pathogenic factors, and promoting blood circulation to alleviate the pain. The aim of the study is to compare the Effectiveness of Cupping Therapy on Local points SI.15 (Jianzhongshu), GB.21 (Chienching), SI.9 (Chiencheng) and Acupuncture at specific point St.38 (Tiaokou) on PAS. Methods: Sixty subjects were randomly assigned into Cupping therapy group (CTG, n=30) and Acupuncture group (AG, n=30). Both groups were assessed at baseline and at the end of 4 sessions for Visual Analogue Scale (VAS), Shoulder Pain and Its Disability Index (SPADI) and the range of motion (ROM). Intervention was given weekly once for four weeks. In CTG, Sterile fiber glass cups are placed over the Acupuncture points like SI.15 (Jianzhongshu), GB.21 (Chienching) and SI.9 (Chiencheng) for 20 min. For AG, Sterile needle was placed for 20 min on St. 38 (Tiaokou). Results: Both Cupping therapy and Acupuncture groups, shows improvements within the group in VAS, total SPADI score and ROM. But Cupping therapy shows significant changes in both statistically and clinically in VAS score (p<0.001), pain index (p<0.003), disability index (p<0.002), total SPADI score (p<0.001), shoulder flexion (p<0.005), abduction (p<0.05) and external rotation (p<0.05). Conclusion: Cupping Therapy and Acupuncture may have similar effect in management of shoulder pain and its restriction which was measured through VAS, SPADI and range of motion–flexion, abduction and external rotation. However Cupping Therapy showed higher therapeutic benefits on patients with PAS.