Department of Community Medicine, Mashhad University of Medical Science, Mashhad, Iran
Research Article
Blood Laboratory Study in Acute Promyelocytic Leukemia Patients with FLT3-ITD Mutation
Author(s): Mehdi Mohammadi Kanesbi*, Lida Jarahi, Hossein Ayatollahi and Maryam Sheikhi
Background: Acute Promyelocytic Leukemia (APL) is a well-defined subtype of Acute Myelocytic Leukemia (AML) and known by t (15;17)
(PML-RARA) mutation. 20%-40% of AML patients indicate FMS-Like Tyrosine kinase 3 (FLT3) mutations. FLT3 mutations contain two famous
mutations: FLT3-ITD (Internal Tandem Duplication) and FLT3-TKD (Tyrosine Kinase II Domain).
Objectives: Many studies have been done on FLT3-ITD. These studies have been acknowledged that the FLT3-ITD mutation had poor
prognosis of on AML patients. This study was performed on two APL and APL+FLT3-ITD groups. This study aimed to compare differences
in blood laboratory assays between APL and APL+FLT3-ITD patients.
Methods: This study contained 73 patients which divided in two groups: Acute promyelocytic leukemia and FLT3-ITD+acute
promyelocytic leu.. Read More»
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