Alternative & Integrative Medicine

ISSN: 2327-5162

Open Access

Articles in press and Articles in process

    Editorial Note Pages: 1 - 1

    Editorial Note: Journal of Alternative & Integrative Medicine Reports

    Rajajeyakumar Manivel

    The New year promises many exciting developments for Journal of Alternative & Integrative Medicine (AIM). Popularity of the AIM can be ascertained by the reader’s interest, curiosity and support, which is estimated from the response we have been receiving from diverse geographical regions all across the world. This is further ratified by the Google Analytics metrics that analyses and releases our reader’s profile from time to time and the total numbers of page views are 1017. Moreover, the number of citations per year continues its robust rise as articles enjoy increasingly broad dissemination. The journal is now getting indexed in different academic forums. All these are promising signs. Congratulations to all of our Editorial Board members, reviewers, authors and readers for achieving this distinction.

      Case Report Pages: 1 - 3

      Role of Homoeopathy in Management of Diabetes Mellitus

      Nirav Rugahni

      Pancreas has a great role in metabolism by secreting the necessary juices, enzymes & hormones. Considering the endocrine gland it play major role in maintenance of blood sugar level in every part of body by secreting insulin through Beta cells of pancreas. If either insulin secretion gets hampered by any way from the pancreas or the cellular receptor at the end organ fail to receive the insulin and ultimately poor uptake of sugar at the cellular level then problems starts. Initially, cells tries to adapt by finding out other resources in and surrounding of the cells and cellular places and get the sugar, and does not produce symptoms. Many a times homoeostasis and adaptive mechanism at long run does not allow the organism to express any signs and symptoms and that is how we are getting many cases of silent suffering of Diabetes Mellitus without any direct symptoms of disturbance in metabolism. Symptoms started to appear at the end organ cellular level where the disturbance seen in insulin uptake for sugar metabolism and cells does not get enough sugar. Eventually particular part of that cellular organ throws out few expressions and as a physician, we have to identify these expressions and diagnose the disturbance of sugar metabolism or we can say diabetes mellitus.

        Review Article Pages: 1 - 2

        The Role of Meditation in Post-COVID-19 Condition

        Ankita Rai*

        Novel COVID-19 pandemic is shifting the outlook of the world on every materialistic thing. After each departing day, there are some points for optimism and agony both. Researchers are doing their best to slow down this contagious disease. Slowly the recovery rate is also boosting up. Now a new challenge is approaching up as post-recovery phase symptoms or follows up symptoms. Among the recovered individuals the mental symptoms like depression or stress are the most striking ones. The different modalities available for inner peace or reducing the depression, the meditation is most reliable and through different studies done on various parameters most evidence-based also. The practice of meditation in post recovered persons will not only bring inner solace reducing the physiological symptoms but will also reduce spending on health.

          Research Article Pages: 1 - 5

          Evaluation of Distribution and Frequency of Neuroblastoma in Children in Azzahra Hospital of Isfahan between 1996-2007 and 2 Years Survival

          Davood Ershadi*, Mahmood Ashrafi, Mehrdad Memarzade and Ziba Farajzadegan

          DOI: 10.37421/ aim.2022.11..4.382

          Neuroblastoma is more frequent extra cranial childhood malignancy the goal of this study is evaluate pattern of neuroblastoma and 2 years survival in isfahan and comparison with others studies. The counted cases were 45 patients.25 of them were male (55.6%) and 20 of them were female (44.4%). Female/male ratio was 1.25. Primary sites of tumor in 32 patients were retroperitoan (71%), in 8 patients were posterior mediastineum 17.8%, in 3 patients were cervical 6.7% in pelvis 4.4%. In clinical manifestation the abdominal mass is predominant (17 patients 37.8%), abdominal pain in 6 patients 13.3%, abdominal distention in 2 patients (4.4%) fever in 6 patients (13.3%), cervical mass in 4 patients (6.7%), weight loss in 1 patient (2.2%). In evaluation of bone marrow biopsy 22 patient have metastasis to bone (48.8%) and 23 patients have not metastasis (51.1%). In evaluation of peripheral blood smear 29 patient have hypochrome RBC (64.4%) 32 patients have anisocytosis (71.1%), 30 patients have microcytosis (66.7%), 7 patients have low platelets (15.6%), 6 patients have high platelets 13.3%, 5 patients have lymphocytosis (11.1%), 7 patients have atypical lymphocyte (15.6%) 35 cases of them had died (77.8%), and 10 patients had been being alive (22.2%). Statistical analysis show us mean survival of patient with surgical process was 38.8 months and for patient without surgery was 30.6 months. Total 30 month survival in our study was 50%. Female/male ratio (1.25) in our study is same as other studies like a study in Saudi Arabia 53% of our cases was under 20 months 0.44% of them between 20-80 months 3% over 10 years as same result of others study. Retroperitoan is dominant primary site (71%) like other studies. But there is not significant relation between metstatic bone marrow biopsy and survival. Our result about prognosis (30 month survival was 50%) is less than other countries.

            Research Article Pages: 1 - 6

            Blood Laboratory Study in Acute Promyelocytic Leukemia Patients with FLT3-ITD Mutation

            Mehdi Mohammadi Kanesbi*, Lida Jarahi, Hossein Ayatollahi and Maryam Sheikhi

            Background: Acute Promyelocytic Leukemia (APL) is a well-defined subtype of Acute Myelocytic Leukemia (AML) and known by t (15;17) (PML-RARA) mutation. 20%-40% of AML patients indicate FMS-Like Tyrosine kinase 3 (FLT3) mutations. FLT3 mutations contain two famous mutations: FLT3-ITD (Internal Tandem Duplication) and FLT3-TKD (Tyrosine Kinase II Domain).

            Objectives: Many studies have been done on FLT3-ITD. These studies have been acknowledged that the FLT3-ITD mutation had poor prognosis of on AML patients. This study was performed on two APL and APL+FLT3-ITD groups. This study aimed to compare differences in blood laboratory assays between APL and APL+FLT3-ITD patients.

            Methods: This study contained 73 patients which divided in two groups: Acute promyelocytic leukemia and FLT3-ITD+acute promyelocytic leukemia. The study methods included: Cell counting and Peripheral Blood Smear (PBS), karyotype, extraction of mRNA and DNA, cDNA synthesis electrophoresis.

            Results: This study was ruled out on patients involved with acute promyelocytic leukemia in GHAEM hospital Mashhad, Iran. All patients were diagnosed with t (15; 17) (PML-RARA). The age range of patients was 7-63 (mean: 30.86) and 58 (79.5%) (Male: 22, Female: 36) of patients were involved solely with APL and 15 (20.5%) (Male: 10, Female: 5) of them were APL+FLT3-ITD mutation. Blood parameters that were analyzed included: White Blood Cell (WBC), Red Blood Cell (RBC), Hemoglobin (Hb), Hematocrit (Hct), Mean Cell Volume (MCV) and Platelet (PLT) count. Each group of patients’ population was categorized into HIGH Risk factors and LOW Risk factors.

            Conclusion: The consequence of current study demonstrated that FLT3-ITD mutation had a bad effect on laboratory assays in patients involved with Acute Promyelocytic Leukemia.

              Original Research Article Pages: 1 - 4

              Ajayan T, Hari Sankar V, Sugathan NV and Chandraja CV

              Background: In 1999, WHO identified Metabolic Syndrome (MetS) as dysglycemia with BMI ≥ 30 kg/m2 , high lipid profile and Blood pressure above 135/85 mm Hg as metabolic syndrome. Scientific and technical advancement of lifestyle has reduced physical activity of people; whereas today’s food and culture ensures increased calorie intake, which along with psychological stress have landed human life in the clutches of metabolic diseases. Homoeopathy has significant efficacy in treating lifestyle diseases like Diabetes, Blood Pressure, Obesity, Insomnia, Heart Problems, Peptic Ulcers etc. The Objective of the study was to manage metabolic diseases homeopathically and monitor their surveillance using standardized physical measurements to collect data on height and weight; hip and waist circumference, family and past history. Methods: Children who fulfill any 3 criteria of metabolic syndrome are enrolled and data were collected in SKHMC case format systematically. Selected children were communicated with the parent and are requested to visit Sarada Krishna Homoeopathic Medical College for advanced studies and treatment after a written consent. Anthropometric measurement of weight, height, waist circumference, Waist Hip ratio, skin fold measures and activity tracker along with the constitutional medicine was the intervention. Follow up was conducted for a period of 6- 8 months to record significant differences in parameters. Results: The prevalence of the MetS was seen in 19 children among 264 screened students 7.2% among which 3.4% were females; 3.7% were males. All 19 children had BMI above 85percentile; among which obese children were 8 and remaining 11 were identified overweight. The factor responsible were identified as low physical activity, sedentary activities such as watching television or using electronic gadgets and sleep routines, which were seen in 63% of the children and rest was understood as due to medication, family history etc. After the prescription of constitutional remedy and follow up of 8 months, following parameters were analyzed for observing significant difference in Waist circumference, BMI and Waist Hip ratio, skin fold measures; P=0.001. Conclusion: The MetS is prevalent among school children, and this is due to lack of awareness among students, teachers and parents, therefore school health programs can help the children to lead healthy life style. Introducing Physical education and outdoor games in school must be recommended and made mandatory to raise up a healthy generation. Occassional screening programs to manage obesity and MetS must be intervented.

                Review Article Pages: 1 - 4

                Role of homoeopathic medicine in Osteoarthritis

                Sancharika Bansal*

                DOI: 10.37421/2327-5162.2022.11.412

                Over the past year many studies and clinical trials have been published in the osteoarthritis field. This research is based on how osteoarthritis develop by reporting the pathophysiology, prognosis, diagnosis and its treatments. We can cure osteoarthritis using the homoeopathic law "Similia Similibus Curanter," which aids in the treatment of the disease and by finding out the miasmatic approach.

                Review Article Pages: 1 - 4

                A Review Article on Efficacy of Homeopathy in Iron Deficiency Anemia

                Anjali Dharmani*, Chandramani Parinit, Sumaiya Patel, Seema Kapadiya, Sahiba Jamil and Apurva Dixit

                DOI: 10.37421/2327-5162.2022.11.413

                Iron Deficiency Anemia (IDA) is one of the most common dietary deficiencies, accounting for about half of all instances of anemia. It is widespread in many impoverished nations. In most cases, thorough blood analysis and high serum ferritin levels may be used to diagnose this deficient disease. IDA may develop as a result of physiological pressures placed on developing children, adolescents, and pregnant women. In the case of all patients, however, the underlying reason should be explored. Inevitably, proper therapy of this illness improves quality of life, reduces iron deficient symptoms, and reduces the risk of death. The necessity of a blood transfusion oral iron supplementation and intravenous iron therapy are two therapeutic options. As a result, intravenous iron supplementation is regarded an undesirable technique, and the safety problems connected with this strategy in the event of extremely high dosages or in the context of very high ferritin levels are not well understood. The review's goal is to give a critical overview and up to date information about IDA diagnosis and treatment options.

                    Review Article Pages: 1 - 5

                    Comprehensive Review of the Therapeutic Potential of Ayush-64 against Covid-19.

                    SB Singh*, Poornima Mansoria and Savita Sharma

                    DOI: 10.37421/2327-5162.2023.12.447

                    The global pandemic of the Corona virus disease (COVID-19) has caused widespread morbidity and mortality globally. The complicated pathophysiology of COVID-19 and lack of a single therapy have made management a significant issue. Through comprehensive pharmacological, toxicological, and clinical research, AYUSH-64, a poly-herbal formulation developed by CCRAS, ministry of AYUSH, government of India, has demonstrated both its safety and effectiveness in treating infective febrile illnesses like malaria and influenza. Four components in AYUSH-64 include antiviral, immunomodulatory, anti-inflammatory, antipyretic, and anti-inflammatory properties. In COVID-19, it stops the inflammatory responses that lead to substantial morbidity. The government of India has also included AYUSH-64 in the National COVID management protocol based on Ayurveda and Yoga for asymptomatic and mild cases of COVID-19. The study summarizes the therapeutic potential of AYUSH-64 on the basis of clinical trials conducted in India on COVID-19.

                      Research Article Pages: 1 - 7

                      Developing a ?Soo Ul Qinya/Pre Dropsy? Diagnostic Tool (SUQDT) in Traditional Persian Medicine Researches by Weighting and Scoring Disease Signs: A Methodological Review Study

                      Mojdeh Pourhosseini, Hossein Moradi, Fatemeh Nojavan and Abolfazl Mohammadbeigi*

                      DOI: 10.37421/2327-5162.2023.12.467

                      Introduction: Soo ul qinya/pre dropsy is one of the liver diseases that also named as pre-dropsy. But, yet there is no precise method for diagnosis this disease. Therefore, this study aimed to develop “Soo Ul Qinya/Pre Dropsy” Diagnostic Tool (SUQDT) in traditional Persian medicine.

                      Materials and methods: A review study was conducted at 2018 on all 906 books and among credible texts of traditional Persian medicine that have been registered on noor islamic software was checked exactly. Moreover, "soo ul qinya" and "su ul qinya" and "pre dropsy" and "Sualaqani "Pish Istiqa" keywords was used for strategic searches in PubMed, Google Scholar, Scopus and Since Direct, web of sciences, SID and Irandoc. Finally, 15 reference books were chosen. The scoring of "soo ul qinya" signs conducted based on the number of repetition of each signs and symptoms and weighted by inverse-variance method.

                      Results: Of all traditional Persian medicine’s books, 15 title had detailed about "soo ul qinya" disease. Overall, 29 different signs have been pointed in three groups including absolute signs (pallor, edema of feet, hands, face, eyelids), probable but important signs (poor digestion, heavy feeling or fatigue) and probable but less important signs (perspiration decrease, increased appetite). Based on the number of repetitions and sign weight, the final score of each sign will be yielded and the SUQDT developed.

                      Conclusion: The "soo ul qinya" disease is not a well-defined but a diagnostic tool named SUQDT was developed based on different signs of disease and assessing the psychometric properties of it suggested.

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Citations: 476

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