Journal of Blood & Lymph

ISSN: 2165-7831

Open Access

Use of Low-Dose Decitabine with or without Tyrosine Kinase Inhibitors in Advanced Phase Chronic Myelogenous Leukemia: A Systemic Review and Metaanalysis


Maureen Via M Comia*, Charles Eryll S Sy and Jomell C Julian

Reasoning: Movement of Persistent Myelogenous Leukemia (CML) to further developed stages can include hypermethylation, which is connected to opposition or prejudice to imatinib. This hypermethylation has likewise been viewed as a negative prognostic component free of imatinib reaction and from CML stage, consequently decitabine, a hypomethylating specialist, can be an appealing treatment choice for cutting edge stage CML.

Objective: This foundational survey and meta-examination expects to research the job of low-portion decitabine among patients with cutting edge stage CML. Technique: This was performed by the articulation of Favored Announcing Things for Orderly Surveys and Meta-Examinations (PRISMA).

Results: Four (4) studies from 86 articles screened were qualified to be evaluated in this fundamental audit and meta-investigation. These were stage I/II preliminaries including 81 high level stage CML patients and utilized low-portion decitabine (5 to 20 mg/m2), with two examinations utilizing tyrosine kinase inhibitors.

Results of hematologic and cytogenetic reaction, and endurance were evaluated in the meta-examination; with hematologic reaction being leaned toward among cutting edge stage CML patients upon openness with low-portion decitabine (p=0.05). Endurance was likewise preferred among responders to low-portion decitabine, but this was not huge.

Conversation and end: Low-portion decitabine can be a compelling and safe therapy choice in cutting edge stage CML, particularly in additional fragile patients that couldn't endure more escalated chemotherapy regimens.

Notwithstanding, this study is restricted by couple of studies accessible on this point, subsequently further randomized controlled preliminaries can be explored to characterize the job of decitabine and its ideal portion among this subset of patients


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