Journal of Blood & Lymph

ISSN: 2165-7831

Open Access

Morphological Alterations in Megakaryocytes in Bone Marrow Aspirate of Thrombocytopenia Cases


Sharma R, Kiran CM and Ramdas A

Background: Thrombocytopenia is seen in various haematological and non haematological conditions and has been defined as platelet count less than 1.5 lakh/mm3. Dysplastic changes are well known in Myelodysplastic syndrome (MDS) but these can be seen in other haematological conditions.

Methods: This was a retrospective study done on 100 bone marrow aspirations in a tertiary care center in South India from Jan 2015 to Dec 2016. All bone marrow aspirations in this study period was retrieved and the slides were reviewed by two pathologists.

Results: Total of 100 cases were included in the study. Out of 100 cases of bone marrow aspiration, 78 cases were of thrombocytopenia, 6 cases were of thrombocytosis, and 16 cases were of normal platelet count. The most common cause for which bone marrow aspiration was sought was pancytopenia (30 %), followed by ITP (15%), PUO (12%), Anaemia (10%). Bicytopenia (8%), Hepatosplenomegaly (3%), Lymphoproliferative disorder (5%), GMCSF treatment (1%),MPN (3%), T.B , MM (4% each), MDS (2%), AL (2%), MGUS (1% ). Conclusion: Most common cause of thrombocytopenia in this study was pancytopenia followed by ITP. Dysplastic features were seen in MDS but also present in other conditions like megaloblastic anaemia and acute leukemia.


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