Nuclear Medicine & Radiation Therapy

ISSN: 2155-9619

Open Access

Intra-arterial 177Lu-DOTATATE Therapy in Patients with Metastatic Neuroendocrine Tumours in Liver Dominant Disease “A Novel Theranostic Approach to Augment Therapeutic Potential”: Feasibility and Safety Profile


Sundaraiya S, Rajan A, Palaniswamy M, Uthappa MC, Ramprabhu and Venugopal K

Purpose: The aim of the study was to assess the feasibility, safety, tolerability and efficacy of intra-arterial infusion of 177Lu-DOTATATE in patients with well differentiated liver dominant metastatic NET.

Method: Four patients with well differentiated grade II liver dominant neuroendocrine metastasis (Ki67 index ≤ 20%) were included in this study with 68Ga-DOTANOC avid liver metastasis with or without extra hepatic disease. Each patient underwent intra-arterial (IA) administration of 7.4 GBq 177Lu-DOTATATE through selective hepatic arterial catheterization, along with amino acid infusions over 4-6 hours at intervals of 8-12 weeks, with a total of 12 cycles (two patients received 4 cycles of IA infusion, third received only two cycles of IA infusion and the last one received 2 cycles IV followed by 2 IA cycles). All patients received 30 mg long acting octreotide (LAR) on day 5 of 177Lu-DOTATATE therapy. Follow up imaging with 68Ga-DOTANOC PET/CT whole body scan was done after 8 weeks of completion of the second and fourth cycles of 177Lu-DOTATATE respectively and compared with baseline imaging to determine response to treatment. Complete blood counts including platelet counts were monitored on a weekly basis until they reached nadir levels. The clinical response, safety and toxicity profiles as well as tumor markers were assessed pre and post treatment, with a time frame of up to 3 months after last treatment.

Results: All patients tolerated the IA infusion of 177Lu-DOTATATE therapy well, with none experiencing any significant procedure related acute side effects. None of the patients developed acute radiation induced liver disease or renal toxicity. Only one patient developed grade 1 to 2 hematological toxicity. Remaining others was stable with none developing severe grade 3 or 4 hematological toxicity. Only one patient developed transient increase of hepatic enzymes, which normalized subsequently with no decrease in the total bilirubin levels. None of them showed compromise in their quality of life, with a definite improvement in one of them. Two patients showed partial response to therapy according to RECIST criteria and patients showed stable disease. None of them had disease progression. All 4 patients reported significant improvement in symptoms and sense of well-being after treatment initiation. Concordant decrease in serum chromogranin A levels were seen in two patients. Although there was rise in the serum chromogranin A in one patient, he showed good partial radiological response, was asymptomatic, clinically well with no deterioration in his performance status.

Conclusion: Our initial experience of IA administration of 177Lu-DOTATATE therapy in patients with liver dominant metastases is promising, feasible, safe and tolerable. The preliminary therapeutic potential of this therapy is encouraging. However, further prospective studies are needed to show its impact in improving clinical outcomes, median survival and progression free survival.


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