Journal of Blood & Lymph

ISSN: 2165-7831

Open Access

Coombs Negative Hemolytic Anemia of Unknown Origin in Pregnancy


Sunday Alfred Dominico, Mubarakali Janmohamed, Alex Magesa, Hyasinta Jaka, Peter F Rambau and Anthony N Massinde

Hemolytic anemia is very common during pregnancy especially in malaria endemic areas and it is usually an autoimmune condition. Coombs negative or idiopathic hemolytic disease during pregnancy is very rare and it has not yet been described in sub-Saharan countries.

A 34-year-old grand-multiparous woman was referred at our facility at a gestation age of 22 weeks with features of severe anemia in pregnancy, and a history of receiving a blood transfusion (seven units). Several investigations including a Coomb’s test were done. However, there were hardly any derangements, except for initial low hemoglobin. Coombs negative haemolytic anaemia of unknown origin was the final concluded diagnosis. She was treated with a course of glucorticoids, hematenics and a total of 36 units of blood transfusion. She finally delivered a premature baby at 35 weeks of gestation. She recovered completely during puerperium and was discharged the seventh day postpartum with a hemoglobin of 10g/dl. She was lost to follow up.

Coombs Negative Hemolytic Anemia in pregnancy is likely to respond to blood transfusions in conjunction with glucocorticoid therapy.


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