Vitamins & Minerals

ISSN: 2376-1318

Open Access

Current Issue

Volume 9, Issue 1 (2020)

    Review Article Pages: 1 - 4

    Frequency of Micronutrient Deficiencies in Patients with Inflammatory Bowel Disease

    Sarmiento-Aguilar A, Parra-Holguin NN and Yamamoto-Furusho JK

    DOI: 10.4172/2376-1318.1000187

    Background: Inflammatory Bowel Disease (IBD), which includes Ulcerative Colitis (UC) and Crohn’s Disease
    (CD), carries an increased risk of micronutrient deficiencies. There are no previous data in this respect regarding
    Mexican patients, and as genetic and cultural context can make their nutritional state differ.
    Objective: The aim of this study is to describe the frequency of Vitamin D (VD), Cobalamin (Cbl), Zinc and folic
    acid (B9) deficiencies in Mexican patients with IBD.
    Methods: We reviewed medical records from 270 patients with IBD belonging to the Inflammatory Bowel Disease
    Clinic at the National Institute of Medical Science and Nutrition Salvador Zubirán. Clinical and sociodemographic data
    were registered. Statistical analysis was performed using the following cut points: VD insufficiency (21-29 ng/mL), VD
    deficiency (<20 ng/mL), Cbl deficiency (<180 pg/mL), Zinc deficiency (<60 μg/dl) and B9 deficiency (<6 ng/mL).
    Results: Of the total 270 patients studied, 224 had UC (82.96%) and 46 (17.03%) CD. A total of 225 had VD
    registered measures, from them, 108 (48%) VD insufficiency and 76 (33.8%) VD deficiency; 159 (58.9%) patients had
    registered Cbl levels, from them, 22 (13.8%) showed deficient levels. Of the 71 (26.29%) patients with registered Zinc
    serum levels, 5 (7%) presented deficiency. From the 166 (61.48%) patients with B9 registered levels, deficiency was
    found in 5 (3.01%) of them.
    Conclusion: The frequency of micronutrient deficiencies in IBD patients was: 48% for VD insufficiency, 33.8% for
    VD deficiency; 13.8% for Cbl deficiency, 7% for Zinc deficiency and 3.01% for B9 deficiency.

    Research Article Pages: 1 - 4

    Erythrocyte and Serum Folate Collection Techniques: A Multi-Method Study of Folate Status

    Croff et al., 2020, 9:1

    DOI: 10.4172/2376-1318.1000188

    Introduction: Public health programs aimed at identifying and monitoring individuals at risk of specific nutrient
    deficiencies may benefit from advances in biospecimen sampling techniques that allow for easier in-the-field collections.
    Such advances may be particularly important for those of childbearing potential, in order to identify individuals at risk
    of low folate status due to sub-optimal nutriture. Folate is a critical nutrient of interest among women of childbearing
    potential because suboptimal levels are a primary contributor to neural tube defects. Whatman Paper Dried Blood
    Spots (WDBS) are a convenient method for assessing folate; however, a major drawback of WDBS has been the
    inability to separate serum from erythrocyte folate in these samples.
    Aim of study: The purpose of this study was to test the feasibility of using newer linear flow chromatography DBS
    cards to measure serum and erythrocyte folate.
    Method: A convenience sample (n=27) was recruited to assess folate values collected by venous blood draw,
    Whatman paper, and linear flow chromatography cards. These sampling techniques allowed for assessment of
    erythrocyte and serum folate values collected via different methods. Folate levels in the samples were assessed using
    standard Lactobacillus casei microbiological assays.
    Results: Erythrocyte folate values from the two blood spot methodologies (Whatman paper and linear flow
    chromatography DBS) indicate a strong linear relationship, with 92% of variance accounted for in a linear regression
    analysis. Similarly, venous blood samples and linear flow chromatography DBS values accounted for 88% of the
    Conclusion: Linear flow chromatography dried blood spot cards are useful for assessment of erythrocyte and
    serum folate. Values had a strong, positive, linear relationship to serum and erythrocyte folate values from other
    validated methodologies, including Whatman dried blood spots and venous whole blood samples.

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