Title: Calcineurin levels and activity in breast cancer: Relation to apoptosis

European Chemistry Congress

June 16-18, 2016 Rome, Italy

Abeer A A Khamis, Manal Basyouni Ahmed, Maha Imam Ahmed and Muneera Al-Sheeha

Ain Shams University, Egypt
Qassim University, Saudi Arabia
Tanta University, Egypt

Posters & Accepted Abstracts: Chem Sci J

Abstract :

Background: Calcineurin (CN) is a Ca2+/calmodulin- dependent phosphatase and has been implicated in both transcriptiondependent and transcription-independent apoptosis. Objectives: We aim to interpret the correlation between calcineurin and apoptosis in relation to pathogenesis of breast cancer. Design and methods: Both calcineurin level and activity as well as caspas-3 activity were evaluated in tissue homogenate of 50 breast cancer patients, 20 patients with fibroadenoma and 15 healthy women. Results: Calcineurin activity was significantly low in malignant compared to benign and normal groups (P=0.00) without significant changes in its level (P> 0.05). While caspase-3 showed a significant higher activity in malignant group compared to other groups (P<0.05). Moreover, there was a significant negative correlation between calcineurin activity with grade, stage (P=0.01), caspase-3 (P=0.002) and a significant positive correlation with its level (P=0.039). Conclusion calcineurin activity but not its level has an important role in breast neoplasia, restoration of its normal activity may be act as adjuvant factor of apoptosis and control breast cancer pathogenesis.

Biography :

Abeer Abdel Hamid Ahmed Khamis  is from the department of  Biochemistry from Tanta University, Egypt.
Email:Lamarbasel2013@yahoo.com