Yonghua Wang and Wenjuan Zhang
Northwest A & F University, China
Posters & Accepted Abstracts: Altern Integr Med
Traditional Chinese medicine (TCM) is known to be essential in maintaining and improving human health for thousands of years. The strategy to discover new drugs from TCM has proved to be very successful. However, due to the complexity of chemical components and mechanisms of action, a search and understanding of therapeutic molecules from TCM based on the traditional method is extremely difficult. In recent times, the confluence of spectacular advances in systems pharmacology has led to the discovery and development of numerous novel potential drugs and therapeutic agents for the treatment of a wide spectrum of diseases. In this work, we attempted to introduce how to apply systems pharmacology for the novel drug discovery from TCM. The systems pharmacology integrated ADME/t prediction, pharmacokinetics and systems biology to uncover the action mechanisms of TCM. The new advances of systems pharmacology could be widely applied in investigation the basic theory of TCM, optimization of old formulae and novel drug development. Our study is not intended to be an exhaustive one of comprehensive approach for TCM, but rather is aimed at highlighting the invaluable role that natural products have played, and continue to play, in the drug discovery process and its future perspectives.
Alternative & Integrative Medicine received 413 citations as per Google Scholar report