The new steroids from Silene montbretiana

Medicinal Chemistry

ISSN: 2161-0444

Open Access

The new steroids from Silene montbretiana

6th World Congress on Medicinal Chemistry and Drug Design

June 07-08, 2017 Milan, Italy

Hilal Kilinc, Milena Masullo, Tamer Karayildirim, Sonia Piacente and Ozgen Alankus

Dokuz Eyl???¼l University, Turkey
Ege University, Turkey
Salerno University, Italy

Scientific Tracks Abstracts: Med Chem (Los Angeles)

Abstract :

Silene genus (Caryophyllaceae) is represented by 119 species, wild and cultivated, in Middle and East Anatolia, Azerbaijan, Iran and Iraq. Due to its wide range of biological and pharmacological effects, Silene species are used as herbal medicine. S. gonosperma, S. morcrooftiana W., S. edgeworthii, S. chlorifolia, S. acaulis, S. floscuculi L. and S. vulgaris have been used in the treatment of eye and skin problems, dysentery, inflammation, colic, malaria and stomach pains, urinary infection, respectively. S. vulgaris has been used for its sedative effect and as an anti-toxic agent. Modern biological studies have shown that Silene species exhibit a wide range of biological actions. It has been reported that S. armeria L. showed moderate antifungal activity against all plant pathogens. S. swertiifolia and S. spergulifolia had a high antibacterial activity against gram negative and positive bacteria. S. montbretiana was collected from Malatya, Turkey in 2010. Air-dried and powdered whole plant material was extracted with MeOH. After filtration, the residue was dissolved in water and then partitioned n-BuOH saturated with H2O. The n-BuOH phase was fractioned over RP-VLC to give eight main fractions. Fractions were subjected to open column chromatography by using normal and reverse phase silica gel as adsorbents. This is the first study that describes the isolation and identification of secondary metabolites from S. montbretiana. In this study, two new steroids (SM 4, SM 16) 2???²,3???²,14???±,20S,25- pentahydroxy-cholest-7-en-6-one, 3-O-???²-D-glucopyranosyl,25- O-???²-D-glucopyranosyl-3???²,25- dihydroxycholest-7-en-6-one, along with eight known compounds (six steroids, one flavonoid, and one cerebroside) were isolated from the methanolic extract. Their structures were elucidated by extensive spectroscopic methods including 1D- and 2D-NMR techniques as well as ESIMS and HRMS analyses.
This work is supported by T??BITAK (114Z226) and Ege University Research Foundation (2012-Fen-047).

Biography :

Hilal Kilinç has completed her PhD from Ege University and has received scholarship from the scientific and technological research council of Turkey for 4 months to study at Salerno University under the supervision of Professor Sonia Piacente. Her studies focused on isolation, purification and structural elucidation of secondary metabolites.


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