Eman H Esmail, Hadeel M Sief, Inas Yassine and Aiman A Albasmi
Cairo University, Egypt
Kasr Al-Ainy Hospitals, Egypt
Posters & Accepted Abstracts: J Neurol Disord
Background & Purpose: Pathology of Juvenile Myclonic Epilepsy (JME) is related to thalamocortical dysfunction. Putamen is closely related to thalamocortical circuit. The purpose of this study is to evaluate microstructure of thalamo-cortica-striatal circuit in JME patients. Materials & Methods: A case control study was conducted on 13 JME patients and 9 age and sex matched volunteers as control subjects. They were studied using diffusion tensor imaging (DTI) at frontal white matter, thalamocortical fibers in internal capsule and both putamens. Results: Ten female and three male patients completed the study and their age was 23.38├?┬▒4.75. Patients had less mean FA in thalamocortical tracts compared to control subjects (p=0.014). No statistically significant difference was found between patients and control subject in other regions of interest. Conclusion: This study demonstrates micro-structural abnormality in thalamocortical tracts, but not putamin in JME patients.
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