Systems biology of gene and metabolic regulation by estrogen receptors and kinases in breast cancer

6^th International Conference on Bioinformatics & Systems Biology

August 22-23, 2016 Philadelphia, USA

Zeynep Madak Erdogan

University of Illinois at Urbana-Champaign, USA

Posters & Accepted Abstracts: J Comput Sci Syst Biol

Abstract :

The importance of kinases in diseased physiology is well known, as increased kinase activity through phosphorylation, mutations or increased expression is often observed in clinical samples and is associated with a poorer prognosis. However, the mechanisms underlying the interplay between ER�± and protein kinase pathways in cancer and metabolic disease, and the processes by which ER�± influences these pathways are poorly understood. The main aim of our study is to elucidate the crosstalk and interrelationships between ER�± and extranuclear initiated and direct nuclear pathways using integrated OMICs approaches, including RNASeq, ChIPSeq, metabolomics, microbiome analysis and biomarker panel analysis. We will discuss about our recent findings on how these kinase pathways impact ER actions in the nucleus in breast cancer and metabolic syndrome associated with menopause.

Biography :

Email: zmadake2@illinois.edu