Osama Y Abu Tammam
The paper introduces Monte Carlo Area Algorithm using Mat lab simulation to generate uniform random distribution points and evaluate the area accordingly and analyze the error. The method to calculate the error had done by comparing the real area value and estimated area values the repetition of the algorithm introduce superior efficiency and reduce the difference between real area value and estimated which considered as error. The relation between Error and number of random points is obviously an exponential relation which affected by number of repetition and random points. The true challenge in such studies is to limit the deviation in the exponential relation between error and number of random points.
Moses Orimoloye Akinjiyan*, Olusola Olalekan Elekofehinti, Ayomide Precious Ajiboro, Elizabeth Foluke Awodire, Adeodotun Olayemi Oluwatuyi and Stephen Adeleke Adesida
DOI: 10.37421/0974-7230.2022.15.432
Erectile Dysfunction (ED) has been a threat among couples and is one of the challenging disorders in Nigeria and the world. Various drugs targeting Phosphodiesterase 5 (PDE5) inhibition like Pyrazinopyridoindole (Tadalafil), have been used for the treatment of ED but, they are associated with side effects such as headache, diarrhea, back pain, and stomach upset among others. Medicinal plants are now being explored for the treatment of various diseases and disorders including ED because they are affordable with little or no side effects. Cissus populnea (CP) is a popular plant in Nigeria used in the management of ED but there is a paucity of information on the mechanisms involved. In this study, Schrodinger suites were employed for docking of thirty-eight CP phytocompounds gotten from HPLC analysis and works of literature against Phosphodiesterase PDE5, a key enzyme in the erection pathway. Seven leading compounds were found to have higher docking scores and binding affinity compared to Pyrazinopyridoindole (Tadalafil), with 9-octadecenoic acid, having the highest docking score of -13.078 Kcal/mol. The hit compounds were further subjected to ADME prediction. The findings suggested that C. populnea compounds are potential drug candidates with better hit than Tadalafil in managing ED and merit additional investigation.
DOI: 10.37421/0974-7230.2023.16.452
Smaranya Dey, Subhadip Paul, Uddipto Dutta and Anirban Chatterjee
Mahboobeh Zohourian, Marzieh Shekari, Hossein Zamani and Moftakhar Ahmadi
Journal of Computer Science & Systems Biology received 2279 citations as per Google Scholar report
