Synthesis of novel spiro dipyrazolo[3,4-b: 4΄,3΄-e]pyridine

2^nd International Conference on PHARMACEUTICAL CHEMISTRY

October 02-04, 2017 Barcelona, Spain

Bahman Ebrahimi Saatluo and Mehdi M Baradarani

University of Urmia, Urmia, Iran

Posters & Accepted Abstracts: Med Chem (Los Angeles)

Abstract :

Green chemistry synthesis of spiro[dipyrazolo[3,4-bÃ?Â?:4Ã?Â?,3Ã?Â?-e]pyridines derivatives are reported under basic conditions. 1,4-dihyrdopyridines have attracted much attention in both synthetic and biological research, as a class of calcium modulators are extensively investigated. Pyrazole derivatives display a wide range of biological and pharmalogical activities for example, fungicidal, herbicidal. Spiro pyrazole-1,4-dihyrdopyridine moieties have shown important biological activities, such as anti-HIV, antibacterial, antiviral, cyclooxygenase inhibiting activites. Another family of this heterocyclic compounds with notable pharmacological activities are dipyrazolo pyridine compounds, as selative or anti-asthmatic compounds. Dipyrrazolopyridine are much attractive in the synthetic and medicine target for researcher, owing to their significant fluorescence, biological and pharmacological activities such as anti-cancer agent, hypotensive, cytotoxic and anti-bacterial activity. In additional, spiro[dipyrazolo[3,4-bÃ?Â?:4Ã?Â?,3Ã?Â?-e]pyridines system although less investigated exhibit also very promising biological agents, due to the presence of three effective functional of pyrazole, 1,4-dihyropyridine moieties and spiro framework, spiro- heterocyclic ring is rather exciting that gives structural rigidity to the compounds by conformational restrictions and therefore considerably increasing and effecting the biological activities. As a part of our ongoing interset in this context, we reported a simple and facile synthesis of a new type of spiro[dipyrazolo[3,4-bÃ?Â?:4Ã?Â?,3Ã?Â?-e]pyridines with Et3N catalyst starting from hydrazine derivatives, ethyl acetoacetate, 3-methyl-1-phenl-1H-prazol-5-amine and 5,6-dihydro-1H-pyrrolo[3,2,1-ij] quinolone 1,2(4H)-dione in environmentally friendly solvent of ethanol.

Biography :

Bahman Ebrahimi Saatluo received his degree in Applied Chemistry from the Urmia University. He will receive his Ph.D degree in Organic Chemistry from the Urmia University (Iran) in 2017 after completing his research in the study of synthesis of polyazadodecahedrone and synthesis of spirooxindole compounds of 1,2,3,4- tetrahydroqunoline by base , acid and nano catalysts under the guidance of Professor Mohamah Mehdi baradarani. His current research interest focuses on the synthesis of spirooxindole and supramolecular in heterocyclic for organic synthesis.