Synthesis of doxorubicin-containing ionic liquid and study of its biological activity

Medicinal Chemistry

ISSN: 2161-0444

Open Access

Synthesis of doxorubicin-containing ionic liquid and study of its biological activity

5th International Conference on Medicinal Chemistry & Computer Aided Drug Designing and Drug Delivery

December 05-07, 2016 Phoenix, USA

Ksenia S Egorova, Fedor A Kucherov, Alexandra V Posvyatenko and Valentine P Ananikov

Russian Academy of Sciences, Russia

Posters & Accepted Abstracts: Med chem

Abstract :

Ionic liquids (ILs), or molten salts, possess unique physicochemical and biological properties. The major advantage of ILs is their high tunability: practically any desirable features can be combined within one IL molecule. According to a novel API-IL (active pharmaceutical ingredient â?? ionic liquid) concept, traditional drugs can benefit from being used in the ionic liquid form. API-ILs is suggested to solve such major drawbacks of many traditional medicines as low solubility and polymorphism. In this work, we used this concept to synthesize API-IL, which contained doxorubicin as a biologically active moiety. Doxorubicin is a DNA intercalating agent commonly applied for treatment of various types of cancers. We introduced the doxorubicin moiety into an imidazolium IL via an amide bond to obtain the resulting API-IL (1-(doxorubicin- 10-carboxydecyl)-3-methylimidazolium bromide). We studied cytotoxicity of the obtained DOX-IL towards Colo 320HSR cells (colon adenocarcinoma) in comparison with cytotoxicity of the pure doxorubicin chloride and 1-(10-carboxydecyl)- 3-methylimidazolium bromide. According to preliminary results, doxorubicin and DOX-IL demonstrated comparable cytotoxicity towards Colo 320HSR cells (24-h IC50 â?¼6-9 ?¼M), whereas the IL without the doxorubicin moiety was significantly less cytotoxic (24-h IC50 >3000 ?¼M). Thus, introduction of doxorubicin into an ionic liquid did not disturb the biological activity of the drug. The results evidence promising potential of the API-IL strategy for pharmaceutical research.

Biography :

Ksenia S Egorova graduated from Lomonosov Moscow State University with a Master of Science in Biochemistry in 2006. In 2010, she completed her PhD in Molecular Biology at the Institute of Molecular Genetics RAS (Moscow, Russia). Since 2012, she has been a researcher at N D Zelinsky Institute of Organic Chemistry. She is an author of 19 papers and three book chapters. Her interests include biological activity, natural products, cancer proteomics, ionic liquids and carbohydrate research.


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