Synthesis of antifungal compound from isolated curcumin

Joint Event on 23^rd International Conference on Advanced Materials & 10^th International Conference on Chemistry Education and Research

June 20-22, 2018 Oslo, Norway

Manal Y Sameeh

Umm al-Qura University, Saudi Arabia

Posters & Accepted Abstracts: J Chem Sci

Abstract :

Turmeric belongs to the ginger family and is a rhizomatous herbaceous perennial plant. It may be considered the strong effective nutritional supplement in existence. It has revealed numerous medical studies about the importance of turmeric in the treatment of a large number of illnesses beginning of cancers, leading to Alzheimer disease. Turmeric is the spice which gives curry yellow color. This study investigates the best methods to isolate, purify, and identify the chemical composition and the important biological activity of turmeric. At the beginning, the turmeric was bought from market and followed by: 1) The plant used in research was classified as Turmeric (Curcuma longa L.) , By Dr. Kadri Nabih Sayed Abdul Khaliq, Professor of Plant Classification at Umm Al Qura University. 2) The percentage of moisture in the dried samples was assessed. The results showed that the moisture content of turmeric tubers was 12%. 3) Various compounds of dry turmeric rhizomes were extracted by ethanol , GC-MS was achieved to this extract and showed the presence of a large number of compounds belonging to different types of terpenes and aromatic compounds. The largest component of these compounds was the turomene (19.0%), zingiberen (17.0%) and curcumene (20%). 4). Isolation of curcumin from ethanolic extract. 5). Synthesis of curcumin epoxide by using mcpba thermally. 6). Antifungal activity was done to new compound " curcumin epoxide" with the fungi (Candida albican, Aspergillus parasiticus, Fusarium proleferatum, Penicillium verrucosum and Aspergillus niger) and the results were highly positive.