Synthesis and study of novel helical and helicene-like compounds

Medicinal Chemistry

ISSN: 2161-0444

Open Access

Synthesis and study of novel helical and helicene-like compounds

International Conference on Stereochemistry

August 18-19, 2016 Sao Paulo, Brazil

Ashutosh V Bedekar

M S University of Baroda, India

Posters & Accepted Abstracts: Med chem

Abstract :

Molecules possessing ortho-fused aromatic rings, acquire a unique shape in order to release the internal strain. This type of molecular arrangement acquires helical structure and shows stereoisomerism. The helical molecules have attracted much attention in recent years due to some unique properties associated with its structure. The efficient delocalization of ???¯??????°-electrons and non-planarity of the structure in the helicenes enable them to be stable to strong acids and high temperature. The applications of helical molecules cover a wide range in the fields of material science, asymmetric synthesis and catalysis, as molecular motor, in biology etc. A number of approaches have been developed for the synthesis of these screw shape molecules due to efforts required to overcome the inherent steric factors or steric crowding. In this presentation results of our efforts towards the synthesis and study of some helical molecules will be presented.Synthesis of a number of helical and helicene-like molecules, investigation of their structural aspects, attempts for the separation of their isomers and study of their optical and thermal properties will be discussed. The molecules show high thermal stability and interesting optical properties.

Biography :


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