Synthesis and biological evaluation of Schiff base derivatives of furfural based heterocyclic flavonoids

Joint Event on 23^rd International Conference on Advanced Materials & 10^th International Conference on Chemistry Education and Research

June 20-22, 2018 Oslo, Norway

Hari Babu Bollikolla and Bala Murali Krishna Khandapu

Acharya Nagarjuna University, India

Posters & Accepted Abstracts: J Chem Sci

Abstract :

Synthesized a total number of 12 new furfural flavone Schiff base derivatives starting from commercially available phloroglucinol. In the first stage of the corresponding acetophenone key intermediate was synthesized from the starting material and was condensed with furfural followed by cyclisation, and formylation. Finally, the formylated flavone was condensed with various aromatic primary amines to obtain the desired Schiff base derivatives. All the synthesized furfural flavone Schiff base derivatives were tested for their anticancer and antibacterial activities and the results were analysed in the light of their structural activity.