Synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine derivatives as breast anti cancer

International Conference on Pharmaceutical Chemistry

September 05-07, 2016 Frankfurt, Germany

Khaled M H Hilmy

Monufyia University, Egypt

Posters & Accepted Abstracts: Med chem

Abstract :

Compounds 2a-c obtained through reaction of 1a-c with benzonitrile. On the other hand, compounds 3a-c, 4a-i and 5a-f were synthesized. Also, some new 7,8-diaryl-3H-imidazo[1,2-c]pyrrolo[3,2-e]pyrimidin-2(7H)-ones 6a-c were obtained through reaction of compounds 3a-c with ethyl glycinate. The synthesized compounds 2a-c, 4a-i, 5a-f and 6a-c were tested for in-vitro antitumor activity against the breast cancer (MCF7). Some of the tested compounds exhibited cell growth inhibitory activity. Also, compounds 6a, 6b, and 6f (with IC50 values 2.13, 2.28, and 2.28���¼g/mL) respectively are more active than Doxorubicin (with IC50 value 2.97 ���¼g/mL).

Biography :

Khalid M H Hilmy has completed his PhD from Azhar University Cairo, Egypt and Post-doctoral studies from Odense University Chemistry Department, Odense, Denmark. He has published more than 40 papers in reputed journals.

Email: hilmykhaled@yahoo.com