Shaima El Mowafi
National Research Centre, Egypt
Scientific Tracks Abstracts: Med Chem (Los Angeles)
One of the greatest threats to human health in the twenty-first century is the development of antibiotic resistance. Gramnegative pathogens are remarkably successful in evading antibiotic action, due to their ability to maintain the integrity of their cell envelope. Recently, a cyclic octapeptide, named SI24, was identified from a genetic screen as an inhibitor of the ├Ć┬?E cell envelope-sensing pathway, which is required for the virulence and viability in several Gram-negative pathogens. SI24 was found to be toxic to E.coli bacterial cells when expressed in vivo, but was not, however, an effective inhibitor when added exogenously, probably because it cannot cross the cell envelope. On the other hand, positively charged antimicrobial peptides have been considered as potential therapeutic sources of future generations of antibiotics for treating resistant pathogenic microbes because of their broad-spectrum activities. These candidates have been developed as cell-penetrating peptides (CPPs) and have become one of the emerging vehicles for delivery of cargo drugs. We thus hypothesize that conjugation of the cyclic peptide inhibitor SI24 with CPPs could enhance its permeability, and consequently its activity against bacterial cells, providing a paradigm for the development of antibiotics targeting a novel pathway in Gram-negative pathogens.
Shaima El-Mowafi has completed her PhD from the Pennsylvania State University in 2014. She is currently a Postdoctoral Researcher at the National Research Centre in Egypt.
Medicinal Chemistry received 5231 citations as per Google Scholar report