Synthesis & anti-inflammatory screening of some novel 2-azetidinones/4-thiazolidinones bearing 1,3,4-thiadiazole nucleus

4^th International Conference on Medicinal Chemistry & Computer Aided Drug Designing

November 02-04, 2015 Atlanta, USA

Byran Gowramma, Gomathy Subramanian, Rajagopal Kalirajan and Palaniswamy Dhanabal

J S S University, India

Posters-Accepted Abstracts: Med chem

Abstract :

The oxidative cyclization of thiosemicarbazone (I) was carried out using ferric chloride as an oxidative agent to get 2-amino-5- styryl-1,3,4-thiadiazole (II). 2-amino-5-styryl-1,3,4-thiadiazole (II) reacted with aromatic aldehydes in methanol to give the new product N-(4-sustituted)-5-styryl-1,3,4-thiadiazol-2-amine (IIIa-h). Compound (IIIa-h) reacted with chloroacetyl chloride in triethylamine to give 2-azetidinone derivatives bearing 1,3,4-thiadiazole nucleus (IVa-h). Compound (IIIa-h) on cyclo condensation with mercaptoacetic acid leads to the formation with 4-thiazolidinone derivatives bearing 1,3,4-thiadiazole ring (Va-h). Synthesis of all titled compounds were confirmed by melting point, IR, 1H-NMR and mass spectrum and evaluated for their anti-inflammatory activity. Out of the synthesized compound IVa and IVb were capable of showing very good anti-inflammatory activity almost on compared with that of the standard ibuprofen, followed by IVc while the rest of compounds were found to be mild in their potency.

Biography :

Email: gowrammab@rediffmail.com