Study on the functional role of immunoglobulin E as surrogate marker for HIV/AIDS infection

Baalaji.S.U, Vaishnavi.B and Andrew Pradeep.M

: J Antivir Antiretrovir

Abstract :

C ertain viral infections are known to produce specific IgE antibodies that significant changes in the level of total serum IgE may occur. Study attempts to associate the Level of IgE in HIV progression. The study involves fifty HIV seropositive patients attending ART Centre, Department of Sexually Transmitted Disease, Rajaji Government Hospital, Madurai, India subjected for the present study. The individual involves 27 HIV/ AIDS Male patients, 23 HIV/ AIDS Female patients. The control sample comprises 15 HIV sero negatives. The samples were collected at the informed consent of the patients. Serum sample were collected and IgE was quantified using MAGIWELL IgE quantitative solid phase Enzyme- linked Immunosorbent assay (ELISA). The study documents highest percentage of deviation from the control observed in Male HIV seropositives (43.7%) and age- wise influence documents highest percentage of deviation in the age group 15- 29 years (56%). Serum IgE level in the study found to be elevated from the normal range documents the existence of imbalance between Th 1 and Th 2 and associated with T-cell dysfunction and a hypergammaglobulinemia. The results suggest that elevation of circulating IgE levels may be due to specific IgE directed to the HIV virus rather than as a result of a nonspecific phenomenon. It indicates that total IgE is increased during the early stages of disease and this elevation appears to be independent of CD4 counts and is not correlated with the levels of other immunoglobulins, suggesting an important role for IgE as a surrogate marker of disease progression Keywords: Reaginic antibody, Hypersensitivity, Hypergammaglobulinemia

Biography :

Mr. S.U.Baalaji is pursuing his master?s in Molecular Virology at King Institute of Preventive Medicine and Research and had done his bachelor?s in Biochemistry at The American College affiliated to Madurai Kamaraj Univesity. During this course of time he had done a short term project on ?Effect of Tamarindus indica L. extracts on DNA damage studies? and presented a paper on ?Recombinant DNA technology in monoclonal antibodies? at the national level seminar organized by Kamaraj College of Engineering and Technology and a presentation on Botulinum Toxin. He is also an active member of the European association of Cancer Research Ms. Vaishnavi.B is pursuing her master?s in Molecular Virology at King Institute of Preventive Medicine and Research and had done her bachelor?s in Biotechnology at SRM Arts and Science College affiliated to University of Madras. Presented a paper in National conference on biotechnology intervention for conservation and sustainable utilization of Bioresources (BICSUB) conducted by Sathyabama University. Actively participated in National Conference on ?Molecular Perspectives and Therapeutic Strategies for Influenza? organized by King Institute of Preventive Medicine and Research and Influenza Foundation of India