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Journal of AIDS & Clinical Research

ISSN: 2155-6113

Open Access

Articles in press and Articles in process

    Review Article Pages: 1 - 5

    Knowledge, Attitude and Practice of Community and Hospital Pharmacists towards the Novel Coronavirus Disease 19 (COVID-19)

    Endalkachew Mekonnen Eticha* and Workineh Diriba Gemechu

    Background: Cases of COVID-19 have been increasing in number and spread globally. Pharmacists are an important part of the health care system and their role is critical in completing the management cycles of Coronavirus outbreak surveillance. Methods: A multi-centric cross-sectional study was conducted on 84 pharmacy professionals recruited from both community and hospital pharmacies in Jigjiga City to assess the knowledge, attitude and practice towards COVID-19. Self-administered questionnaires were developed and distributed to the participants. All extracted data were cleaned, coded and entered into the Statistical Package for the Social Science software version 20 and subsequently analyzed. Binary logistic regression analysis was used to identify determinants of knowledge, attitude and practice towards COVID-19. Results: All of the respondents had already heard about COVID-19. More than 90% of the participants had adequate knowledge regarding typical symptoms, etiological causes, modes of transmission, measures to protect the infection, risky patients and primarily affected organ system by COVID-19. The majority of the respondents (71.4%) had adequate knowledge regarding COVID-19. The finding indicated that pharmacists had 8 times higher odds (AOR=8.34 95% CI (1.33-36.04)) of adequate knowledge than the pharmacy technicians. Greater than half of the study participants (53.6%) had a positive attitude towards COVID-19. More than 4 out of 5 participants were confident that Ethiopia can win the battle against the pandemic. Participants with less than five years of experience had 6 times greater odds (AOR=6.16; 95% CI (1.52-24.86)) of a positive attitude than their comparator. A low number of participants (16, 22.6%) exercised adequate practice to prevent and control the novel coronavirus spread. Conclusion: The community and hospital pharmacists had good knowledge but had a poor attitude and practice towards the COVID-19. The majority of the participants perceived that they can play a great role in this pandemic.

      Editorial Pages: 1 - 1

      Comparing HIV Testing Strategies in Uganda: Is Assisted Partner Testing More Yielding in HIV Testing?

      Vian Namanya*, Dickens Owamaani and Edmund Byamukama

      DOI: DOI: 10.37421/2155-6113.2022.13.891

      HIV remains a global human threat with about 39 million people infected and it has claimed the lives of over 25 million over the last 25 years. Over 80% of these are in sub-Saharan Africa. As of 2019, Uganda had an estimated population of 41.5 million, of whom 1,915,533 live with HIV/AIDS with HIV incidence among susceptible individuals at 1.4%, the ultimate highest. About 53000 people were infected with HIV in 2018 whereas 23000 died of the illness in Uganda in 2018. In Uganda, 84% of the people living with HIV knew their status, 72% were on ART and 64% were virally suppressed. Among adults (15-64 years, the most sexually active), the prevalence is 6.2%. In western Uganda, the prevalence stands at 7.9% slightly below western Nile with the highest at 8%. 

      Review Article Pages: 1 - 9

      The Effect of Azithromycin and 4-Aminoquinoline-Based Regimens in COVID-19 Positive Pregnant Women: A Systematic Review

      Vian Namanya* and Kalema Bashir Amza

      DOI: DOI: 10.37421/2155-6113.2022.13.892

      Introduction: Worldwide the efficacy and safety of Azithromycin and 4-Aminoquinoline regimen in the treatment of COVID-19 has remained uncertain in both pregnant and other mothers. Pregnancy complications studies are still lacking, although a high preterm birth rate due to the combination of this regimen has been reported which is mostly caused by iatrogenic preterm birth owing to the diagnosis of COVID-19 principally preterm cesarean deliveries and perinatal transmission may occur but seems rare. There is lack of evidence reporting an increase in the incidence of congenital abnormalities, an increase in stillbirth or neonatal death (miscarriages), Fetal Growth Restriction (FGR) among pregnant mothers with COVID-19.

      Aim: This study aimed at systematically reviewing studies regarding the use of Azithromycin and 4-Aminoquinoline based regimens in COVID-19 positive pregnant mothers.

      Methods: This was asystematic literature review. A systemic search of articles was done on PubMed, TRIP, EPPI COVID Living Map, Web of Science, and medRxiv databases until 2020 using the keywords “COVID-19”, “SARS-CoV-2”, “coronavirus”, “hydroxychloroquine”, and “mortality”. Relevant articles were chosen for further evaluation based on a review of their titles and abstracts. In vivo and in vitro studies were included assessing the safety and effectiveness of Azithromycin and 4-aminoquinline for treatment of COVID-19 pregnant mothers.

      Results: A total of 438 articles were screened and 12 eligible clinical studies (seven peer-reviewed and published studies and five non-peer-reviewed studies from pre-print servers were included) selected. A number of studies have established very good virological and clinical outcomes with 4-Aminoquinoline in particular HCQ therapy alone or in combination with Azithromycin among COVID-19 pregnant mothers. However, some studies have shown negative results with combination of HCQ treatment and Azithromycin among COVID-19 pregnant mothers.

      Conclusion: In this systematic review, we have found that the results of effectiveness and safety of Azithromycin and 4-aminoquinoline combination in COVID-19 pregnant mothers as obtained from 12 eligible clinical studies, is not satisfactory, although many of these studies had major methodological limitations. Stronger evidence from well-designed robust randomized clinical trials is required before conclusively determining the role of Azithromycin and 4-aminoquinoline combination regimen in the treatment of COVID-19. Clinical prudence is required to advocate of Azithromycin and 4-aminoquinoline combination regimen as an unmitigated therapeutic armamentarium in pregnant mothers with COVID-19. Also, the potential of HCQ as a chemo-prophylactic agent against COVID-19 needs to be explored.

      Review Article Pages: 1 - 6

      Risks, Diagnosis and Treatment of Preeclampsia In Western Uganda: Do Health Workers Know What To Do?

      Vian Namanya* and Ubaldo Sobimana

      DOI: DOI: 10.37421/2155-6113.2022.13.872

      Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality Worldwide. The risk of maternal death is much more common in developing countries than developed countries. Therefore it is necessary to recognize the signs and symptoms to predict the disease before it threatens the survival of both mother and fetus since it complicates about 3% of all pregnancies. Health workers like midwives, clinicians and doctors are the primary care givers in treating, understanding and explaining preeclampsia, its diagnosis, risk factors and complications as delay in diagnosis and prompt initiation of treatment could result in disastrous consequences for both the mother and the baby. The risk of maternal death is very high in lower health centers where there no enough trained doctors and other HWs. There is also inadequate supply of drugs used in management of preeclampsia. The study seeks to ascertain whether there are gaps in knowledge and practices by health workers in Bushenyi district contributing to the nationally high mortality rate in rural areas due to pre-eclampsia.36 health workers handling preeclampsia mothers in Bushenyi district were randomly selected and administered a questionnaire to assess their skills and knowledge. Study found that most health workers knew about preeclampsia, its risks but 46% knew less about HELLP syndrome. This study also finds that 52% of the health workers could not adequately prescribe magnesium sulphate and 46% could not signs of magnesium toxicity.

      The researchers recommend more refresher course for health workers in Bushenyi and Uganda at large as well as emphasizing use of preeclampsia phone applications and strengthening hands on training for students in health training institutions.

      Perspective Pages: 1 - 1

      Improving HIV Patient Appointment System among Homosexual Men-A Bushenyi Medical Centre (BMC) Experience

      Vian Namanya and Isaac Mugume

      Bushenyi Medical Centre (BMC) in Western Uganda has an HIV/ AIDS programme with over 5000 clients in care, 3200 (60%) on ART of whom 10 are homosexual men (MSM). Uganda has about 1.9 million people living with HIV.

        Research Article Pages: 1 - 6

        Prevalence and Risk Factors of Anaemia during HIV Infection in Bangui

        Gaspard Tekpa, Sylvain Honore Woromogo*, Eudes Gbangba Ngai, Valentin Fikouma, Larissa Eleonor Kpengougna, Prince Wilikoe and Boniface Koffi

        DOI: DOI: 10.37421/2155-6113.2022.13.906

        Background: Haematological manifestations during HIV infection in Bangui are common and poorly documented. The objective of our study was to evaluate the frequency of anaemia before and during antiretroviral treatment in people living with HIV (PLHIV) and to identify associated factors.

        Methods: This was a retrospective analytical study covering the period from 1 January 2012 to 31 December 2016. PLHIV who were naive or had been treated with ARVs for more than six months and whose medical records included a blood count and a CD4 T-cell count were included. Sociodemographic and clinicobiological characteristics were collected using an anonymous questionnaire. The prevalence of anaemia was measured before and at the sixth month of antiretroviral treatment. Multiple logistic regressions were used to identify associated factors.

        Results: We included 532 patients of whom 149 were men (28%). The average age was 37.5 ± 9.4 years. The patients were seen in stages 3 and 4 of the WHO classification of HIV infection in 70.81% of cases. The mean CD4 T cell count increased from 201 ± 175/mm3 before antiretroviral therapy (ART) to 361 ± 182/mm3 after six months of ART. Risk factors for anaemia in PLHIV before ART were CD4 200/mm3 (p=0.0391) and thrombocytosis (p=0.0083); on ART, anaemia was associated with cotrimoxazole use (p=0.0285) and thrombocytosis (p=0.0212).

        Conclusion: Anemia in PLWH is common and has multiple risk factors, some of which are preventable, such as late treatment and tuberculosis. Better knowledge of risk factors, early detection and management could help reduce anaemia-related morbidity and mortality.

          Research Article Pages: 1 - 11

          Knowledge of HIV and AIDS and Predictors among Students at Nelson Mandela University in South Africa

          Given Mutintaa*

          Background: Knowledge about HIV and AIDS is important in promoting safer sexual behaviour. Given that there is no vaccine or cure for HIV and AIDS, knowledge about HIV and AIDS is an important enabler in the prevention efforts. The aim of the study is to investigate HIV and AIDS knowledge and predictors among students at Nelson Mandela University in South Africa.

          Methods: The study was conducted using cross-sectional and quantitative research methodology among students at Nelson Mandela University. Stratified sampling was employed to select 884 undergraduate students. A self-administered questionnaire was used to collect data analysed using SPSS version 26. A bivariate and multivariable binary logistic regression model was employed to identify predictors of HIV and AIDS knowledge. The p-value <0.05 and odds ratio with 95% confidence interval were used to determine statistical significance of the findings.

          Results: Findings show that 52.5% of the students had good knowledge about HIV and AIDS. Having a monthly stipend >2000 rand from parents/relatives (AOR=2.71 (1.35–5.49)), being in the third year level of study and higher up (AOR=5.35 (2.93–9.77)), and being in the health science faculty (AOR=16.29 (8.22–32.29)) were significant predictors of good level of HIV and AIDS knowledge.

          Conclusion: Almost half of the students reported poor knowledge about HIV and AIDS. There were misconceptions about HIV transmission routes among students. Monthly income, level of the study, and faculty of study were reported to be significant predictors of HIV and AIDS knowledge. This study calls for the need to provide students with more HIV and AIDS education to address HIV and AIDS knowledge gaps and promote behavioural change.

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Citations: 4463

Journal of AIDS & Clinical Research received 4463 citations as per Google Scholar report

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