Role of Urinary Exosomal microRNAs as Biomarkers for Early Detection of Acute Kidney Injury in Critically Ill Patients

24^th Annual Conference on Urology and Nephrological Disorders

April 10-11, 2025 | Webinar

Priya Nair

All India Institute of Medical Sciences, India

Scientific Tracks Abstracts: J Nephrol Ther

Abstract :

Acute kidney injury (AKI) is a common and serious complication in intensive care units, often diagnosed late by serum creatinine changes. Urinary exosomal microRNAs (miRNAs) have emerged as potential non-invasive biomarkers reflecting renal injury at early stages. This study profiled miRNA expression in urinary exosomes from 80 critically ill patients to identify AKI-specific signatures. Using qRT-PCR, miR-21, miR-146a, and miR-155 were significantly elevated in patients developing AKI within 48 hours compared to controls. Receiver operating characteristic analysis showed these miRNAs had high diagnostic accuracy (AUC >0.90). Integration of miRNA levels with clinical parameters improved early AKI prediction. Urinary exosomal miRNAs represent promising biomarkers for timely AKI diagnosis, enabling earlier intervention to improve outcomes.

Biography :

Priya Nairs research interests include biomarker discovery and renal pathophysiology. She has published extensively on molecular diagnostics in kidney diseases and leads ongoing projects on non-invasive biomarkers for AKI.