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Receptor occupancy in flow cytometry: A key PK/PD option in biologics clinical studies
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Journal of Bioanalysis & Biomedicine

ISSN: 1948-593X

Open Access

Receptor occupancy in flow cytometry: A key PK/PD option in biologics clinical studies


10th International Conference and Exhibition on Biologics and Biosimilars

October 16-17, 2017 | San Francisco, USA

Anka G Ehrhardt

Bristol-Myers Squibb Co., USA

Scientific Tracks Abstracts: J Bioanal Biomed

Abstract :

Receptor occupancy assays are a key method in dose escalation studies to understand the amount of drug required to cover the available receptors during patient dosing, as well as to deliver PK data for PK/PD work. For many biologics, flow cytometry assays utilizing peripheral blood are well suited for receptor occupancy studies, and are used often in the clinic. This presentation will summarize some of the common considerations and different versions of RO assays in the context of clinical studies.

Biography :

Anka G Ehrhardt is a Biophysicist with a Doctorate degree in Human Physiology. She is currently working in the United States Building and directing a team applying the latest technologies in support of the development of new live saving drugs

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Citations: 3099

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