Jucelia Stadinicki dos Santos, Ribeiro C E L, Almeida S M and Raboni S M
Universidade Federal do Parana, Brazil
Instituto de Pesquisa Pele Pequeno Principe, Brazil
Posters & Accepted Abstracts: J AIDS Clin Res
In this study, we evaluated the HIV-1 features, the clinical and epidemiological profile of LTNPs patients treated in a referral hospital from Curitiba, Paran├?┬í, Southern Brazil. Medical records were reviewed and periodic blood draws were held for tests aimed to determine the genetic variability of HIV-1 and to evaluate the host innate and genetic patterns. To date, 23 patients, corresponding to 1.64% of patients followed at the Infectious Diseases Division from HC/UFPR were identified as LTNPs. The gender distribution is homogeneous (56% female) with a median age of 45 years (range 12-62 years). The risk behavior for HIV-1 infection was sexual activity in 65% (73% were heterosexual), vertical infection in 22% and use of injectable drugs in 13% of the cases. The median time of HIV-1 diagnosis was 13.5 years (range 9-23 years) and the median count CD4+ T lymphocytes of 702 cells per mm3 (range 569-890). Regarding host protective factors, we observed a frequency of protective HLA-B alleles in 20/22 (91%) of analyzed individuals. Deletion of the CCR5 co-receptor gene encoding was investigated in all patients and it was found in four (17.4%). The genotypic HIV-1 evaluation showed subtypes C (52%), B (30%) and recombinants BC and BF (18%). Tropism prediction was consistent with an R5 phenotype in almost all study patients (95%). Several mechanisms, both viral and host, appear to be associated with the status of this Cohort of HIV+ LTNP. Data obtained to date well characterized our group LTNPs studied as described in the literature with profile related to a delayed clinical progression. As most studies on LTNPs and HIV pathogenesis were carried out with subtype B, further research is needed to elucidate the host-viral interactions in individuals with various clades of HIV-1, seeking to clarify the reasons for their slow progress, consequently being important for future therapeutic options for HIV infection.
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