Phytochemical screening and antitumor effect of ethanol extract of Egyptian wild plants

European Chemistry Congress

June 16-18, 2016 Rome, Italy

Thoria Diab and Thoria Donia

Tanta University, Egypt

Posters & Accepted Abstracts: Chem Sci J

Abstract :

It was proposed for decades that natural products are more safe in therapeutics as compared to synthetic drugs. The aim of this study was to screen ethanol extracts of four Egyptian plants (Varthemia candicans, Peganum harmala, Suaeda vermiculata and Conzya dioscoridis) to study their antioxidant activity in vitro using DDPH (50% DDPH inhibition) and phosphomolybdate assays (as equivalent ascorbic acid/g dry weight), in addition to the total phenolic and flavonoid contents were estimated to find possible sources for future novel antioxidants in food and pharmaceutical formulations. Moreover, the anticancer activity of plants extracts against HepG2 cells using MTT assay was studied. The results revealed that Varthemia candicans extract was the highest one in both polyphenol and flavonoid contents. Furthermore, 50% DDPH inhibition showed that Suaeda vermiculata extract exhibit lowest IC50 against DDPH indicating it is the most effective. Taken together, the four investigated plants extract showed a potent antioxidant and antitumor activities that hold great promise to identify new natural therapeutic drugs. Further work is needed to study the mode of action of different extracts and more analyses to study their in vivo anticancer activities.

Biography :

Thoria Diab did her PhD from Paul Sabatier University, Toulouse, France. She has 3 papers in reputed journals, Journal of Hepatology is one amongst them. She ahs presented a abstract in a conference in France, and a chapter in an electronic book (Advnces in Genome Science, Chapter 6).
Email:thoria.abdelaziz@yahoo.com