University of California, USA
Scientific Tracks Abstracts: J Neurol Disord
We recently found that valproic acid suppresses palmitoylation of neural proteins including AKAP5 (AKAP79/150). Reduced AKAP5 palmitoylation disrupted regulation of the M-current, which is generated by neural Kv7 channel family. Various neurotransmitters that activate Gq-coupled receptors suppress M-current and increase neuronal excitability. We show that palmitoylation is required for receptor-induced M-current supprssion. Similar disruption of M-current suppression was observed by inhibition of acyl-CoA synthetase. These results might fill in a gap between lipid metabolism and its anticonvalsant action.
Naoto Hoshi has completed his MD/PhD at Kanazawa Unviersity (Japan) and became a junior faculty there. He moved to the lab of Dr. John D. Scott, (Howard Hughes Medical Institute/Oregon Health Sciences University at the time). He now is in University of California, Irvine. His primary interest is physiological and pathological relevance of neuronal K7.2 channel modulation.