Isolation and structure elucidation of phytochemicals from sponges of Okinawa, Japan

2^nd International Conference on Medicinal Chemistry & Computer Aided Drug Designing

October 15-17, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

Gabriel Adeyemi Francis, Chiaki Tanaka and Tomofumi Miyamoto

Accepted Abstracts: Med chem

Abstract :

Investigations of marine secondary metabolites revealed the presence of various poly-acetylenic compounds in marine organisms especially in marine sponges which has been attributed to various biological activities. This is a report of an on-going research into the anticancer properties of phytochemicals from sponges of Okinawa, Japan against Hela cells which has been identified as the causative pathogen of pelvic cancer. The EtOH crude was partitioned between Et 2 O, n-BuOH and H 2 O. Component isolation of the Et 2 O fraction was achieved using a combination of open column chromatography, flash column chromatography and HPLC while spectra analysis of isolates from the Et 2 O fraction using 1 HNMR, 13 CNMR, COSY, DEPT, HMBC, HSQC, TOCSY, NOESY AND MS revealed Pellynol A which was active against Hela cells at 1μg/ml and other poly-acetylenes.

Biography :

Gabriel Adeyemi Francis was awarded the Japanese MEXT scholarship in 2011 to undergo a Ph.D. program at the Natural Product Chemistry Laboratory, Graduate School of Pharmaceutical Science, Kyushu University, Japan, under the supervision of Associate Professor Tomofumi Miyamoto and Assistant Professor Chiaki Tanaka. He obtained M.Sc. degree in Organic Chemistry from the University of Abuja, Nigeria. His current research focus is on isolation and structure elucidation of bioactive marine secondary metabolites as novel analogs in drug discoveries against cancer cell lines.