Is anti-RA 33 has specificity and sensitivity in diagnosis of early rheumatoid arthritis?

Neurological Disorders

ISSN: 2329-6895

Open Access

Is anti-RA 33 has specificity and sensitivity in diagnosis of early rheumatoid arthritis?

2nd International Conference on Neuroimmunology & Therapeutics

December 01-02, 2016 Atlanta, USA

Mahin Lashkari, Noori A, Hajiimanouchehri F, Oveisil S and Kazemifar A M

Qazvin University of Medical Sciences, Iran

Posters & Accepted Abstracts: J Neurol Disord

Abstract :

Rheumatoid arthritis is a chronic inflammatory disease with uncertain etiology. It is characterized by symmetric polyarthritis in peripheral joints. Its diagnosis is based on clinical findings and serologic tests. Diagnosis of RA is based on its typical signs and symptoms, with laboratory and radiographic confirmation. However, its diagnosis is rarely conclusive in early course of the disease. So, its early diagnosis could be difficult. The present study was designed to evaluate the role of anti-RA33; an auto-antibody against RA33 in early diagnosis of the disease. Forty three patients with RA who had been visited in a rheumatology clinic were randomly selected. Their disease has been diagnosed by a rheumatologist. They served as the case group. 55 persons were also chosen from healthy individuals who had attended in other clinic. They served as control. Their age and sex were matched with the case group. The level of anti -RA33 was compared between the groups. It was measured by ELISA. The cut-off point curve of its level was drawn, in which the sensitivity, specificity, and negative and positive predictive values of the test have been calculated, as well as its age correlation, and its association with RF. Anti-RA33 and RF titers were measured in their blood sample using standard methods. According to findings, RF and anti-RA33 titers had significant correlation in the case group (p=0.015). Anti-RA33 test had 98% sensitivity, 20% specificity, 50% positive predictive value, and 90% negative predictive value. Anti-RA33 could have diagnostic and prognostic importance in diagnosis and evaluation of patients with RA, and its differentiation from other small joint disorders, particularly when the other serologic tests are negative. The current study showed that anti-RA33 test can be used as diagnostic clue for recognition of RA.

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