Lahore College for Women University, Pakistan
Posters & Accepted Abstracts: Med Chem (Los Angeles)
In designing and development of drug products from active drugs, some of the important non-therapeutic substances, termed as excipients, are essentially included. The most important part of a medicine is constituted by its excipients, which have the important functions of guaranteeing the dosage, stability and bioavailability of the active principle. Various excipient interactions e.g. with active drug component and packing material, etc., may render the excipient harmful for use in formulation. In order to avoid the use of incompatible excipients and to assure that the excipients are safe and stable for use in the designing of the formulation, various stability testing procedures are carried out. Studies of drug-excipient compatibility represent an important phase in the pre-formulation stage for the development of all dosage forms. Sugars such as xylitol, sorbitol, etc., are being used as an alternative low calorie sweetener and well accepted in formulations of various confectioneries and healthcare products. In the present work, intermolecular interactions of pharmaceutical excipients (D-sorbitol and xylitol) in water and binary solvent mixture of water and organic solvent (DMSO) have been investigated using an easy approaching volumetric and acoustic method. Binary solvent mixtures of different molar ratios help to explore the effect of different mediums on various volumetric and acoustical parameters like apparent and partial molar volume, thermal expansion coefficient, partial molar expansibility, Hepler├ó┬?┬?s constant, compressibility factor, intermolecular free length, relative association and hydration number have been calculated using density and sound velocity data of pharmaceutical excipients in binary solvent mixture at different temperatures (293.15 K-313.15 K). Results give an insight about various physical and chemical interactions that an excipient molecule can undergo in biological system along with an active drug product. Presently, positive apparent molar volume and decrease in intermolecular free length with increasing excipient concentration is an indicative of strong intermolecular interactions.
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