GET THE APP

Innovative Hydrogel-Based Biomaterials for Controlled Drug Delivery in Wound Healing Applications
Journal of Bioengineering & Biomedical Science

Journal of Bioengineering & Biomedical Science

ISSN: 2155-9538

Open Access

Innovative Hydrogel-Based Biomaterials for Controlled Drug Delivery in Wound Healing Applications


10th Annual Conference and Expo on Biomaterials

April 14-15, 2025 Webinar

Sarah T. Lawson

University of Michigan, Ann Arbor, USA

Posters & Accepted Abstracts: J Biomed Sci

Abstract :

Statement of the Problem: Bone defects resulting from trauma, tumors, or congenital conditions remain a clinical challenge. Traditional grafts pose limitations such as donor site morbidity and immune rejection. The development of biomimetic, biodegradable scaffolds offers a promising alternative for promoting bone regeneration. This study presents a novel 3D-printed composite scaffold using polylactic acid (PLA) and hydroxyapatite (HA) for bone tissue engineering. Methodology : A PLA/HA composite was formulated with 70:30 weight ratio. The scaffold was fabricated using fused deposition modeling (FDM) 3D printing to create porous structures with interconnected architecture. Mechanical properties were evaluated using a universal testing machine, and degradation rates were monitored in simulated body fluid (SBF) over 8 weeks. Biocompatibility was assessed using human osteoblast-like cells (MG-63), and cellular proliferation was measured via MTT assay. SEM imaging was conducted to visualize cell attachment and morphology. Results: The printed scaffolds demonstrated adequate compressive strength (4.5 MPa), aligning with cancellous bone requirements. Degradation analysis revealed gradual mass loss (22% over 8 weeks), suggesting favorable resorption kinetics. MTT assay indicated enhanced cell proliferation in PLA/HA scaffolds compared to PLA alone. SEM images confirmed excellent cell adhesion, with elongated osteoblastic morphology and extensive filopodia formation. Conclusion & Significance: The PLA/HA composite scaffold exhibits promising mechanical integrity, biocompatibility, and degradation characteristics suitable for bone regeneration. Its ability to support cell proliferation and osteointegration makes it a strong candidate for further in vivo evaluation. The use of 3D printing provides precision customization, enabling patient-specific scaffold design for orthopedic applications.

Biography :

Sarah T. Lawson is a renowned biomedical engineer specializing in biomaterials and regenerative medicine. She earned her Ph.D. from MIT and currently leads a multidisciplinary lab focused on 3D-printed scaffolds for musculoskeletal repair. Her work integrates materials science, tissue engineering, and additive manufacturing. Dr. Lawson has published over 60 peer-reviewed articles and has been a frequent speaker at international conferences on advanced biomaterials.

Google Scholar citation report
Citations: 307

Journal of Bioengineering & Biomedical Science received 307 citations as per Google Scholar report

Journal of Bioengineering & Biomedical Science peer review process verified at publons

Indexed In

 
arrow_upward arrow_upward