Innovative Hydrogel-Based Biomaterials for Controlled Drug Delivery in Wound Healing Applications

10^th Annual Conference and Expo on Biomaterials

April 14-15, 2025 Webinar

Elena M. Gruber

Vienna University of Technology, Austria

Scientific Tracks Abstracts: J Biomed Sci

Abstract :

Statement of the Problem: Chronic wounds remain a significant medical concern, especially among diabetic and elderly populations. Controlled drug delivery systems using hydrogel-based biomaterials offer a promising strategy for sustained release of therapeutic agents and enhanced wound healing. This study focuses on the synthesis and evaluation of a novel hydrogel composite incorporating chitosan, polyvinyl alcohol (PVA), and silver nanoparticles (AgNPs) for improved antimicrobial properties and controlled drug release. Methodology : Hydrogels were prepared using freeze-thaw cycles to form crosslinked networks of chitosan and PVA. Silver nanoparticles were synthesized in situ within the hydrogel matrix using sodium borohydride reduction. Ciprofloxacin was loaded into the hydrogel as a model antibiotic. Swelling behavior, drug loading efficiency, and in vitro drug release kinetics were assessed. Antibacterial activity was evaluated against Staphylococcus aureus and Escherichia coli. Cytotoxicity and cell viability were assessed using fibroblast cell lines. Results: The developed hydrogels exhibited high swelling ratios (up to 600%), enabling effective drug absorption and release. Drug release followed a biphasic profile with an initial burst followed by sustained release over 72 hours. Hydrogels containing AgNPs showed superior antibacterial activity, with zones of inhibition significantly larger than control samples. Cell viability assays indicated minimal cytotoxicity, confirming the biocompatibility of the hydrogel composite. Conclusion & Significance: The combination of chitosan, PVA, and silver nanoparticles offers a multifunctional hydrogel suitable for controlled drug delivery in wound care. Its excellent swelling capacity, antibacterial effectiveness, and biocompatibility make it a promising candidate for further preclinical testing and potential clinical translation in the management of chronic wounds.

Biography :

Elena Gruber is a leading expert in biomaterials and nanotechnology, focusing on drug delivery systems and tissue engineering. She received her Ph.D. in Polymer Chemistry from TU Graz and currently leads a research group at TU Wien. Her work explores the development of smart materials for healthcare applications, with over 45 publications in top-tier journals. Dr. Gruber is an active member of the European Society for Biomaterials and regularly contributes to international biomaterials forums.