Immunotherapy for brain tumors: Illusion or real prospects?

Neurological Disorders

ISSN: 2329-6895

Open Access

Immunotherapy for brain tumors: Illusion or real prospects?

International Conference on Neurological Disorders & Stroke and Neurooncology

April 24-25, 2017 Dubai, UAE

Pierre-Yves Dietrich

Geneva University Hospital, Switzerland

Posters & Accepted Abstracts: J Neurol Disord

Abstract :

Major advances have recently been achieved in cancer immunotherapy. Strategies launched decades ago, such as tumor antigenspecific therapeutic vaccines and adoptive transfer of tumor-infiltrating lymphocytes, are being complemented by molecular engineering approaches allowing the development of tumor-specific TCR transgenic and chimeric antigen receptor T cells. In addition, the spectacular results obtained in the last years with immune checkpoint inhibitors are transfiguring immunotherapy; these agents being used both as single molecules, but also in combination with other treatment modalities. Implementation of these various strategies is ongoing for more and more malignancies, including tumors located in the brain, raising the question of the immunological particularities of this site. This may necessitate cautious selection of tumor antigens, minimizing the immunosuppressive environment, and promoting efficient T cell trafficking to the tumor. Taking these aspects into account is critical to efficiently design immunotherapy for patients suffering from tumors located in the brain.

Biography :


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