Immune response to surgery: A predictor of postoperative outcomes

10^th International Conference on Surgery and Anaesthesia

May 19-20, 2025 Zurich, Switzerland

Husham Bayazed

Consultant Immunologist, Iraq

Scientific Tracks Abstracts: Surgery

Abstract :

Immune responses following surgical trauma play a crucial role in predicting postoperative outcomes, including healing, recovery, and the development of complications. Postoperative complications, such as infections and delayed recovery, occur in a significant number of the approximately 300 million surgeries performed annually worldwide. This presentation aims to explore the role of immune responses in predicting postoperative outcomes and to examine how immune dysregulation contributes to complications following surgery. A comprehensive review of recent literature was conducted to explore the immunological mechanisms underlying postoperative complications. Studies were retrieved from databases such as PubMed, Google Scholar, and Web of Science, focusing on surgery and immune dysregulation. Special attention was given to recent advancements in single-cell technologies, such as mass cytometry and single-cell RNA sequencing, which have significantly enhanced our understanding of postoperative immune responses. Recent studies have highlighted immune dysregulation as a key determinant of postoperative complications. Earlier research primarily focused on detecting inflammatory plasma markers, which provided important insights into the pathogenesis of these complications. However, recent advancements in single-cell technologies, including mass cytometry and single-cell RNA sequencing, have markedly improved our ability to understand the immunological basis of postoperative complications. These technologies enable the identification of prognostic biomarkers and biological signatures that could predict patient outcomes after surgery. Proteomic technologies and multiomic modeling have significantly advanced our ability to predict the risk of postoperative complications. By analyzing the patient's immune state before surgery, multiomic approaches hold promise for identifying preoperative biomarkers that can predict postoperative recovery. These predictive biomarkers could provide both patients and surgeons with valuable information, allowing for personalized interventions that improve surgical outcomes. However, despite these advances, further studies are needed to refine these predictive tools and accurately assess individual risk factors for postoperative complications. In conclusion, Immune responses following surgery are increasingly recognized as critical predictors of postoperative outcomes. The use of cutting-edge technologies, such as single-cell RNA sequencing and mass cytometry, provides a deeper understanding of immune dysregulation and its role in postoperative complications.Recent Publications 1. Concentration levels of IL-10 and TNFα cytokines in patients with human papillomavirus (HPV) DNA+ and DNA− cervical lesions. Journal of Immunotoxicology (USA). 2012; 9: 168-172. 2. Detection of human papillomavirus DNA in patients with different cervical lesions in Kurdistan Region, Iraq. European Journal of Cancer, 48: 4s -5s 2014. 3. AntiB2 Glycoprotein Autoantibodies Expression as a Potential Biomarker of Stroke in Antiphospholipid Syndrome. Journal of Immunotoxicology (USA). 2008; 5: 93-98. 4. Crisis Intervention Program For Children And Adolescents Preventing Post-Corona Delinquency, Results of Radomized Controlled Trial. Dohuk Medical Journal, Vol18 No.1 (2024) 5. Kids & Covid-19: they are winning with their immunity. Under Publication 2024 as a preprint

Biography :

Husham Bayazed is a retired physician, consultant immunologist, and former lecturer in the College of Medicine at the University of Duhok and Zakho in Iraq's Kurdistan Region. He is interested in clinical immunology, autoimmunity, and cancer immunology and has published more than 26 papers in reputed international journals. He has been serving as a scientific reviewer for many local and international medical journals, in addition to being a Fellow of the International Society of Chemotherapy, Infection, and Cancer (ISC). Furthermore, he is a member of EUROMDnet's Immunology Advisory Board, a member of the World Stroke Organisation, a member of Metabolomics (USA), a member of the American Association of Science and Technology, and a member of the International Society for Engineers and Researchers (ISER).