M Daniela Angione, T Duff, K Roberts, E Scanlan, P Colavita and G S Duesberg
Trinity College Dublin, Ireland
Posters & Accepted Abstracts: J Bioengineer & Biomedical Sci
There is a strong need for the development of new, highly-sensitive, cost effective and reliable tools for the rapid screening of pathogenic viruses and/or bacteria. There are currently few methods that allow for the low-cost detection of specific pathogens at early stages of infection, when medical intervention is advantageous in order to reduce health-related costs. In nature, carbohydratelectin interactions are responsible of the 90% of the infectious diseases, but it has been very little explored due to lack of appropriate transduction tools based on multivalent approaches for efficient recognition. We are proposing a Field-Effect Transistors (FETs) as transducer platforms for lectins detection. Amongst the advantages of FETs are their extensive biocompatibility, relative ease of manufacture, high amplification of the electrical signal output and scalability in arrays. The active layer of the FET consists of conjugated polymers or small organic molecules modified with specific carbohydrates, for the detection of bacterial or viral infections. The development of a Glyco-FET sensors for detecting Lectins provide a label-free, ultrasensitive and selective detection method, offering a very useful diagnostic tool, for the development of Point of Care diagnostics for use in the Health Sector.