Gene expression profiles and protein-protein interaction network analysis in AIDS patients with HIV-associated encephalitis and dementia

4^th International Conference on Medicinal Chemistry & Computer Aided Drug Designing

November 02-04, 2015 Atlanta, USA

Sergey Shityakov, Thomas Dandekar and Carola F�¶rster

University of W�¼rzburg, Germany

Posters-Accepted Abstracts: Med chem

Abstract :

Central nervous system dysfunction is an important cause of morbidity and mortality in patients with Human Immunodeficiency Virus (HIV) infection and the Acquired Immunodeficiency Virus Syndrome (AIDS). Patients with AIDS may or may not present HIV-Associated Encephalitis (HIVE) with viral replication limited to cells of monocyte origin. In order to examine molecular mechanisms underlying HIVE-induced dementia, the GSE4755 affymetrix data were obtained from the Gene Expression Omnibus database and the Differentially Expressed Genes (DEGs) between the samples from AIDS patients with and without HIVE-associated dementia were identified. In addition, Protein-Protein Interaction (PPI) networks were constructed by mapping DEGs into PPI data to identify the pathways that these DEGs are involved in. The results revealed that the expression of 1528 DEGs, which are mainly involved in immune response, regulation of cell proliferation, cellular response to inflammation and cell-cell signaling. The Heat Shock Protein Alpha (HSP90A) and Fibronectin 1 (FN1) were detected as hub nodes with a degree of >130. In conclusion, the results indicate that HSP90A and FN1 have important roles in the pathogenesis of HIVE-associated dementia.

Biography :

Email: Foerster_C@ukw.de, dandekar@biozentrum.uni-wuerzburg.de, E_Shityako_S@ukw.de