First-in-class MCRs coupled with cascade reactions for the generation of molecular complexity

5^th International Conference on Medicinal Chemistry & Computer Aided Drug Designing and Drug Delivery

December 05-07, 2016 Phoenix, USA

Christopher Hulme

The University of Arizona, USA

Scientific Tracks Abstracts: Med chem

Abstract :

The discovery of complexity-generating multi-component reactions (MCRs) is of continued interest to generate chemotypes of potential pharmacological value. This talk describes recent findings over the last 3 years primarily employing MCRs and subsequent post-condensation modifications. Valuable new insights into indole chemistry will also be presented coupled with intriguing MCR-cascade reactions. The operational simplicity and heterocyclic moieties contained in highlighted scaffolds make these protocols attractive for file enhancement, exploration of �drug-like� chemical space, and medicinal chemistry campaigns.

Biography :

Email: hulme@pharmacy.arizona.edu