Ik-Joong Kang and Su-Yeon Kwon
Gachon University, Republic of Korea
Posters-Accepted Abstracts: Med chem
Chitosan is a biopolymer that is usually produced from N-deacetylation of chitin which is extracted from crustacean. It is emerging substance as the promising bio-adaptable material that is harmless to human body. Many researchers have been interested in the chitosan for drug delivery system because of merits such as good absorptivity, biodegradability, and biocompatibility. Drug Delivery System (DDS) has been developed for the best control of drug releasing speed. It makes the drug to be delivered effectively and safely into the targeted living system. The drug used for the research was hydrocortisone, a steroid hormone. Hydrocortisone has been used to make allergic rhinitis medicine. This work was focused on the drug delivery through the nasal mucosa by using chitosan-hydrocortisone-silver nanoparticles. It was performed for an investigation in order to establish the optimal conditions, by changing concentration of hydrocortisone and reaction conditions. Silver nanoparticles have specific properties for the treatment of various diseases. Their extremely large surface area can collaborate with a vast number of ligands and prevent bacterial infections. The properties of silver nanoparticles applicable to patient treatments are under studying in many research groups and animal studies, assessing potential efficacy. In this research, the average size of chitosan-hydrocortisone-silver nanoshell was about 80 nm, was suitable as an drug carrier because maximum size of drug carrier in human body is 120 nm. UV-Vis spectra of chitosan-hydrocortisone-silver nanoshell show the characteristic peak of silver at 420 nm. Also, multi-layered silver nanoshell on the chitosan nanoparticles induced the red-shifted absorption peak and increased the intensity of absorption peak.
Medicinal Chemistry received 6627 citations as per Google Scholar report
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 