Estrogen suppresses the proliferation of hepatocellular carcinoma cells

4^th International Conference and Exhibition on Metabolomics & Systems Biology

April 27-29, 2015 Philadelphia, USA

George G Chen, Jianwai Ren, Billy C S Leung, Rocky Ho and Paul B S Lai

Posters-Accepted Abstracts: Metabolomics

Abstract :

Clinically, hepatocellular carcinoma (HCC) occurs much more frequently to males than females, but, the underlying mechanisms remain largely unknown. In this study the inhibitory effect of estrogen on the proliferation of liver cancer cells mediated by cytochrome P450 1A2 (CYP1A2) is demonstrated, indicating a potential role of estrogen metabolism in preventing the development of HCC. Our data have revealed the importance of CYP1A2 in estrogen metabolism and hepato-carcinogenesis, not only providing new evidence to understand clinical observations of HCC gender disparity, but also identifying potential targets for HCC prevention and treatments.