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Development of Biodegradable PLA/Graphene Oxide Nanocomposites for Enhanced Biomedical Applications
Journal of Bioengineering & Biomedical Science

Journal of Bioengineering & Biomedical Science

ISSN: 2155-9538

Open Access

Development of Biodegradable PLA/Graphene Oxide Nanocomposites for Enhanced Biomedical Applications


10th Annual Conference and Expo on Biomaterials

April 14-15, 2025 Webinar

Ayesha Khan

National University of Sciences and Technology (NUST), Islamabad, Pakistan

Posters & Accepted Abstracts: J Biomed Sci

Abstract :

Statement of the Problem: With growing interest in sustainable and biocompatible materials, poly(lactic acid) (PLA) has emerged as a leading biodegradable polymer for biomedical use. However, its limitations—such as brittleness and low thermal stability—hinder its broader application in tissue engineering and implantable devices. This research focuses on enhancing PLA properties through the incorporation of graphene oxide (GO) to form a nanocomposite with improved mechanical strength, thermal stability, and bioactivity. Methodology : PLA/GO nanocomposites were prepared using a solvent-casting method, with GO dispersed in chloroform and mixed with PLA at varying weight ratios (0.5%, 1%, 2%). The resulting films were characterized using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). In vitro cytocompatibility was assessed using human fibroblast cell lines through MTT assay, and antimicrobial activity was evaluated against E. coli and S. aureus. Results: The inclusion of GO significantly enhanced the thermal degradation temperature and mechanical properties of PLA films. SEM images showed uniform dispersion of GO at lower concentrations, while FTIR confirmed successful incorporation. The 1% GO-PLA composite exhibited the best balance between mechanical performance and biocompatibility. Cell viability remained above 85% after 72 hours, indicating good cytocompatibility. Furthermore, antimicrobial tests revealed noticeable inhibition zones, especially against S. aureus, suggesting added functionality. Conclusion & Significance: PLA/GO nanocomposites show potential as multifunctional biomaterials for use in biomedical implants, wound dressings, and scaffolds. Their biodegradability, mechanical strength, and antibacterial behavior make them ideal for next-generation medical applications. Further in vivo studies are recommended.

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Citations: 307

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