Prasanta J Goutam
The Assam Kaziranga University, India
Posters & Accepted Abstracts: Med chem
Benzene-1,3-diol (resorcinol) is a reagent in manufacturing industries like rubber, plastics, pharmaceuticals, dyes and cosmetics. Effluents from these industries are sources of resorcinol which are of environmental concern. Biological hazards of resorcinol like suppression of thyroid hormone in human, induction of chromatid ruptures in Chinese hamster ovary cells, carcinogenesis in the upper digestive tract, haematological abnormalities due to life time exposure and even fatal cases of resorcinol poisoning are reported for human fetus. Despite these established disadvantages, literatures are found to be insignificant on guest specific receptors for resorcinol. Here we report 1,6-bis(2,6-bis(benzothiazol-2-yl)pyridine-4-yloxy)hexane as the first specific ditopic receptor which selectively recognizes resorcinol among its structurally identical benzene metabolites like phenol, hydroquinone and catechol. A photoluminescence based detection technique has been devised for easy detection of resorcinol. The exact mechanism of supramolecular host guest recognition have been characterized with the experimental evidences from simple spectroscopic techniques (UV├ó┬?┬?visible and NMR spectroscopy), which are again in agreement with the details of photoluminescence studies.
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